Cell Reproduction Quotes

Cancer, we have discovered, is stitched into our genome. Oncogenes [cancer causing cells] arise from mutations in essential genes that regulate the growth of cells. Mutations accumulate in these genes when DNA is damaged by carcinogens, but also by seemingly random errors in copying genes when cells divide. The former might be preventable, but the latter is endogenous [originating from within]. Cancer is a flaw in our growth, but this flaw is deeply entrenched in ourselves. We can rid ourselves of cancer, then, only as much as we can rid ourselves of the processes in our physiology that depend on growth — aging, regeneration, healing, reproduction.

Much of the attention paid to CRISPR these days involves its potential to make inheritable (germline) edits in humans that will be passed along to all the cells of all of our future descendants and have the potential to alter our species. These edits are done in reproductive cells or early-stage embryos. This is what occurred with the CRISPR baby twins in China in 2018, and it is the controversial topic that I will discuss later in this book.

The idea that female choice (conscious or not) can happen after or during intercourse rather than as part of an elaborate precopulatory courtship ritual turns the standard narrative inside out and upside down. If the female’s reproductive system has evolved intricate mechanisms for filtering and rejecting the sperm cells of some men while helping along those of a man who meets criteria of which she may be utterly unaware, Darwin’s “coy female” starts looking like what she is: an anachronistic male fantasy.

As we ascend to the hierarchies of living matter, we find, even on the lowest level observable through the electron microscope, sub-cellular structures-organelles-of staggering complexity. And the most striking fact is that these minuscule parts of the cell function as self-governing wholes in their own right, each following its own statute-book of rules. One type of organelles look as quasi-independent agencies after the cell's growth; others after its energy supply, reproduction, communications, and so on.

How do you expect me to provide you with a demon tear if I don’t have a body? I can’t cry you a goddamn river while stuck in a bronze reproduction of an ugly-ass alchemist. A dead one, at that.” “You can move your eyes,” Navin ventured. “And you’re a demon. Can’t you do some kind of demon magic and produce tears?” “Demon magic? Have you been eating Ironwood mushrooms? Demons don’t do magic. Demons curse. We tear apart reality and feed on the blood of innocents.” Navin shivered. “Stop being so dramatic. You’re hardly in the position to tear apart reality. You’d have trouble tearing open a packet of potato chips right now.” Newton made a horrific snorting sound that might have been laughter. “Ah, dear boy. And you said you weren’t interested in comedy. If only I could cry tears of laughter right now, we’d be peachy.” “Shut up a minute. I’m trying to think.” “I know. I can hear your two brain cells rubbing together.

It is undignified to inject yourself with hormones designed to slow or enhance ovarian production. It is undignified to have your ovaries monitored by transvaginal ultrasound; to be sedated so that your eggs can be aspirated into a needle; to have your husband emerge sheepishly from a locked room with the “sample” that will be combined with your eggs under supervision of an embryologist. The grainy photo they hand you on transfer day, of your eight-celled embryo (which does not look remotely like a baby), is undignified, and so is all the waiting and despairing that follows.

Cancer, we have discovered, is stitched into our genome. Oncogenes arise from mutations in essential genes that regulate the growth of cells. Mutations accumulate in these genes when DNA is damaged by carcinogens, but also by seemingly random errors in copying genes when cells divide. The former might be preventable, but the latter is endogenous. Cancer is a flaw in our growth, but this flaw is deeply entrenched in ourselves. We can rid ourselves of cancer, then, only as much as we can rid ourselves of the processes in our physiology that depend on growth—aging, regeneration, healing, reproduction.

almost every living cell there was already a functioning computer with a huge memory? A mammalian cell had a DNA complement of several billion base pairs, each acting as a piece of information. What was reproduction, after all, but a computerized biological process of enormous complexity and reliability?

Cancer cells are fixed at an age where they are still too young to have learned the rules of the society in which they live. As with so many immature individuals of all living kinds, everything they do is excessive and uncoordinated with the needs or constraints of their neighbors… they are reproductive but not productive.

I find no reason to think that aging is genetically determined. Genes do not provide information for the development of the individual beyond growth and the reproductive process in which the genes are transmitted to the next generation. Once past the reproductive stage, the individual has served the purposes of preservation of the species, and then he is on his own. The wrinkled human face is the victim of gravity and of cumulative errors in the reproduction of cells. Since aging is not programed, but is a badly improvised interference with youthful beauty, we have improvised an operation to counteract its effects. Aging is a form of misinformation. If we get the facts right, you will be able to read it in our faces. ("Motherhood")

Healing Foods When you’re looking to boost the immune system and support the reproductive system, the best foods to concentrate on are wild blueberries, sesame tahini, avocados, black beans, asparagus, apples, spinach, black grapes, and cucumbers. They’ll help by variously providing antioxidants, preventing hot flashes, providing critical nutrients to fortify vital organs, reducing inflammation, and keeping hormone levels balanced. Herbs and Supplements to Address General Symptoms Silver hydrosol: kills viruses, bacteria, and other microbes on contact and supports the immune system. Zinc: kills viruses, boosts the immune system, and helps protect the endocrine system. Licorice root: aids the adrenal glands and helps balance the body’s levels of cortisol and cortisone. L-lysine: impairs the ability of virus cells to move and reproduce. Vitamin B12 (as methylcobalamin and/or adenosylcobalamin): strengthens the central nervous system. Nascent iodine: stabilizes and strengthens the thyroid and the rest of the endocrine system. Ashwagandha: fortifies the adrenal glands and helps balance the production of cortisol.

The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. When I started my research, sirtuins were barely on the scientific radar. Now this family of genes is at the forefront of medical research and drug development. Descended from gene B in M. superstes, sirtuins are enzymes that remove acetyl tags from histones and other proteins and, by doing so, change the packaging of the DNA, turning genes off and on when needed. These critical epigenetic regulators sit at the very top of cellular control systems, controlling our reproduction and our DNA repair. After a few billion years of advancement since the days of yeast, they have evolved to control our health, our fitness, and our very survival. They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.

professor taps his laptop, the images change, and we are lost in the world of red blood cells. The cell’s nucleus is small and round and serves as the cell’s command center. It controls the cell’s growth and reproduction. It is surrounded by a membrane. And on and on. Attached to our petition was Benderschmidt’s full report, including pages of impenetrable stuff on cells and blood. I confess that I have not read it entirely, but something tells me Judge Kumar has.

The tribal differences that erupt into public controversy typically concern sex (e.g., gay marriage, gays in the military, the sex lives of public officials) and death at the margins of life (e.g., abortion, physician-assisted suicide, the use of embryonic stem cells in research). That such issues are moral issues is surely not arbitrary. Sex and death are the gas pedals and brakes of tribal growth. (Gay sex and abortion, for example, are both alternatives to reproduction.)

Pressing a palm against the new mother’s tummy, Eena closed her eyes and let the dragon’s soul kindle. Her mind sensed the fetus, picturing a disproportionately large head and little appendages still developing. She identified a rapid heartbeat pumping vital blood and nutrients throughout the body. She felt breathing-like movements and uncontrolled twitches that the mother could not yet perceive. She was aware of the massive reproduction of cells taking place, forming intricate, detailed anatomy. Here was a life-form. A young boy. He was healthy. So was his mom. It was remarkable.

Jack coughed slightly and offered his hand. “Hi, uh. I’m Jack.” Kim took it. “Jack what?” “Huh?” “Your last name, silly.” “Jackson.” She blinked at him. “Your name is Jack Jackson?” He blushed. “No, uh, my first name’s Rhett, but I hate it, so…” He gestured to the chair and she sat. Her dress rode up several inches, exposing pleasing long lines of creamy skin. “Well, Jack, what’s your field of study?” “Biological Engineering, Genetics, and Microbiology. Post-doc. I’m working on a research project at the institute.” “Really? Oh, uh, my apple martini’s getting a little low.” “I’ve got that, one second.” He scurried to the bar and bought her a fresh one. She sipped and managed to make it look not only seductive but graceful as well. “What do you want to do after you’re done with the project?” Kim continued. “Depends on what I find.” She sent him a simmering smile. “What are you looking for?” Immediately, Jack’s eyes lit up and his posture straightened. “I started the project with the intention of learning how to increase the reproduction of certain endangered species. I had interest in the idea of cloning, but it proved too difficult based on the research I compiled, so I went into animal genetics and cellular biology. It turns out the animals with the best potential to combine genes were reptiles because their ability to lay eggs was a smoother transition into combining the cells to create a new species, or one with a similar ancestry that could hopefully lead to rebuilding extinct animals via surrogate birth or in-vitro fertilization. We’re on the edge of breaking that code, and if we do, it would mean that we could engineer all kinds of life and reverse what damage we’ve done to the planet’s ecosystem.” Kim stared. “Right. Would you excuse me for a second?” She wiggled off back to her pack of friends by the bar. Judging by the sniggering and the disgusted glances he was getting, she wasn’t coming back. Jack sighed and finished off his beer, massaging his forehead. “Yes, brilliant move. You blinded her with science. Genius, Jack.” He ordered a second one and finished it before he felt smallish hands on his shoulders and a pair of soft lips on his cheek. He turned to find Kamala had returned, her smile unnaturally bright in the black lights glowing over the room. “So…how did it go with Kim?” He shot her a flat look. “You notice the chair is empty.” Kamala groaned. “You talked about the research project, didn’t you?” “No!” She glared at him. “…maybe…” “You’re so useless, Jack.” She paused and then tousled his hair a bit. “Cheer up. The night’s still young. I’m not giving up on you.” He smiled in spite of himself. “Yet.” Her brown eyes flashed. “Never.

If they were living, they must be organic, since life depended upon organization. But if they were organized, then they could not be elementary, since an organism is not single but multiple. They were units within the organic unit of the cell they built up. But if they were, then, however impossibly small they were, they must themselves be built up, organically built up, as a law of their existence; for the conception of a living unit meant by definition that it was built up out of smaller units which were subordinate; that is, organized with reference to a higher form. As long as division yielded organic units possessing the properties of life—assimilation and reproduction—no limits were set to it. As long as one spoke of living units, one could not correctly speak of elementary units, for the concept of unity carried with it in perpetuity the concept of subordinated, upbuilding unity; and there was no such thing as elementary life, in the sense of something that was already life, and yet elementary.

What would fly researchers discover at the tips of the reproductive structures? In the immediate environment in which the GSC (germline stem cells) sit? Shangri-La. [...] The experimental biologist J.J. Trentin proposed in 1970 that within the bone marrow and other home locations, there exists 'hematopoietic inductice microenvironment' with the unique ability to serve as a home location for blood stem cells. In the later 1970s, another blood cell expert, R. Schofield, referred to this specialized microenvironment as a 'niche', introducing the term that would stick and eventually, become widely applied to describe the microenvironment surrounding any type of stem cell. Fly biologist H. Lin describes a stem cell niche as 'the Shangri-La, the idyllic hideaway' in which these cells reside. Nestled in the niche, Lin states, stem cells 'thrive to self-renew and to produce numerous daughter cells that will differentiate and age as they leave the paradise'. In other words, the niche is the place that a stem cell is granted its two wishes - allowing it both to remain and to become something else.

Part One—The Lipid Panel. Used to evaluate heart health, this panel comprises of four biological markers representing the four types of fat found in the blood—triglycerides, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Two additional measures of cardiovascular health, homocysteine and c-reactive protein (CRP), may also be measured as part of a more comprehensive profile. These two labs are discussed in Part Six, “Optional Tests” (see page 8). •  Part Two—The Basic Metabolic Panel. The labs used to evaluate metabolism measure blood sugar regulation, electrolyte and fluid balance, and kidney function. Biomarkers included in this panel are glucose, calcium, sodium, potassium, blood urea nitrogen (BUN), and creatinine. •  Part Three—The Hepatic Function Panel. This panel determines how well your liver is functioning by measuring levels of different proteins produced and processed by the liver, like albumin and globulin, as well as liver enzymes. •  Part Four—The Complete Blood Count (CBC) Panel. The lab values measured in the complete blood count (CBC) panel include red blood cells, white blood cells, platelets, and hemoglobin. Maintaining healthy levels of these biomarkers affect your vitality and energy, immune system, and cardiovascular health. •  Part Five—Hormones. Although they are not always included in a routine blood test, hormones should be periodically tested, especially in aging adults. Hormones such as estrogen, testosterone, progesterone, DHEA, and prostate specific antigen (PSA) play an integral role in reproductive wellness and affect other aspects of health. Maintaining balanced levels can slow down the aging process, for instance. Hormones involved in metabolism, like the thyroid hormones and the stress hormone cortisol, are also discussed in this section. •  Part Six—Optional Tests. This final part of the book highlights four tests—homocysteine, c-reactive protein (CRP), vitamin D, and magnesium—that are not typically measured unless requested, or if a standard blood test shows an abnormality that requires a more in-depth analysis. These tests can provide a more complete picture of heart health, immunity, calcium absorption, blood sugar regulation, and a number of other vital processes.

None of these systems, whether “natural” or man-made, can operate without a continuous supply of energy and resources that have to be transformed into something “useful.” Appropriating the concept from biology, I shall refer to all such processes of energy transformation as metabolism. Depending on the sophistication of the system, these outputs of useful energy are allocated between doing physical work and fueling maintenance, growth, and reproduction. As social human beings and in marked contrast to all other creatures, the major portion of our metabolic energy has been devoted to forming communities and institutions such as cities, villages, companies, and collectives, to the manufacture of an extraordinary array of artifacts, and to the creation of an astonishing litany of ideas ranging from airplanes, cell phones, and cathedrals to symphonies, mathematics, and literature, and much, much more. However, it’s not often appreciated that without a continuous supply of energy and resources, not only can there be no manufacturing of any of these things but, perhaps more important, there can be no ideas, no innovation, no growth, and no evolution. Energy is primary. It underlies everything that we do and everything that happens around us. As such, its role in all of the questions addressed will be another continuous thread that runs throughout the book. This may seem self-evident, but it is surprising how small a role, if any, the generalized concept of energy plays in the conceptual thinking of economists and social scientists.

La gauche socialiste se lançait sur la voie d'une mutation profonde, qui allait s'accentuer d'année en année, et commençait de se placer avec un enthousiasme suspect sous l'emprise d'intellectuels néoconservateurs qui, sous couvert de renouveler la pensée de gauche, travaillaient à effacer tout ce qui faisait que la gauche était la gauche. Se produisait, en réalité, une métamorphose générale et profonde des ethos autant que des références intellectuelles. On en parla plus d'exploitation et de résistance, mais de « modernisation nécessaire » et de « refondation sociale » ; plus de rapports de classe, mais de « vivre-ensemble » ; plus de destins sociaux, mais de « responsabilité individuelle ». La notion de domination et l'idée d'une polarité structurante entre les dominants et les dominés disparurent du paysage politique de la gauche officielle, au profit de l'idée neutralisante de « contrat sociale », de « pacte social », dans le cadre desquels des individus définis comme « égaux en droit » (« égaux » ? Quelle obscène plaisanterie !) étaient appelés à oublier leurs « intérêts particuliers » (c'est-à-dire à se taire et à laisser les gouvernants gouverner comme ils l'entendaient). Quels furent les objectifs idéologique de cette « philosophie politique », diffusée et célébrée d'un bout à l'autre du champ médiatique, politique et intellectuel, de la droite à la gauche (ses promoteurs s'évertuant d'ailleurs à effacer la frontière entre la droite et la gauche, en attirant, avec le consentement de celle-ci, la gauche vers la droite) ? L'enjeu était à peine dissimulé : l'exaltation sur « sujet autonome » et la volonté concomitante d'en finir avec les pensée qui s'attachaient à prendre en considération les déterminismes historiques et sociaux eurent pour principale fonction de défaire l'idée qu'il existait des groupes sociaux - des « classes » - et de justifier ainsi le démantèlement du welfare state et de la protection sociale, au nom d'une nécessaire individualisation (ou décollectivisation, désocialisation) du droit du travail et des systèmes de solidarité et de redistribution. Ces vieux discours et ces vieux projets, qui étaient jusqu'alors ceux de la droite, et ressassé obsessionnellement par la droite, mettant en avant la responsabilité individuelle contre le « collectivisme », devinrent aussi ceux d'une bonne partie de la gauche. Au fond, on pourrait résumer la situation en disant que les partis de gauche et leurs intellectuels de parti et d'État pensèrent et parlèrent désormais un langage de gouvernants et non plus le langage des gouvernés, s'exprimèrent au nom de gouvernants (et avec eux) et non plus au nom des gouvernés (et avec eux), et donc qu'ils adoptèrent sur le monde un point de vue de gouvernants en repoussant avec dédain (avec une grande violence discursive, qui fut éprouvée comme telle par ceux sur qui elle s'exerça) le point de vue des gouvernés. Tout au plus daigna-t-on, dans les versions chrétiennes ou philanthropiques de ces discours néoconservateurs, remplacer les opprimés et les dominés d'hier - et leurs combats - par les « exclus » d'aujourd'hui - et leur passivité présomptive - et se pencher sur eux comme les destinataires potentiels, mais silencieux, de mesures technocratiques destinés à aider les « pauvres » et les « victimes » de la « précarisation » et de la « désaffiliation ». Ce qui n'était qu'une autre stratégie intellectuelle, hypocrite et retorse, pour annuler toute approcher en termes d'oppression et de lutte, de reproduction et de transformation des structures sociales, d'inertie et de dynamique des antagonismes de classe. (p. 130-132)

But your genes can also be different from those of your parents just through random mutation, which is the imperfect copying from one strand of DNA to another. It can literally be a cosmic ray from outer space that knocks into one of your genes and changes it. Genes sometimes jump from one place on the DNA molecule to another. These are called transposon genes. It could be that your parent’s eggs or sperm (or a plant’s ova and pollen) got messed with a little by some chemical. It could be radiation from some radioactive elements in Earth’s crust that caused a mutation. Sometimes viruses get into the reproductive cells of an organism and modify its genes. Virus manipulation can also be exploited deliberately—to adjust the genes of corn plants so they are tolerant of aggressive weed killer, for example.

these creatures grow up with a peculiar knowledge. They know that they have been born in an infinite variety. They know, for instance, that in their genetic material they are born with hundreds of different chromosome formations at the point in each cell that we would say determines their "sex". These creatures don't just come in XX or XY; they also come in XXY and XYY and XXX plus a long list of "mosaic" variations in which some cells in a creature's body have one combination and other cells have another. Some of these creatures are born with chromosomes that aren't even quite X or Y because a little bit of one chromosome goes and gets joined to another. There are hundreds of different combinations, and though all are not fertile, quite a number of them are. The creatures in this world enjoy their individuality; they delight in the fact that they are not divisible into distinct categories. So when another newborn arrives with an esoterically rare chromosomal formation, there is a little celebration: "Aha," they say, "another sign that we are each unique." These creatures also live with the knowledge that they are born with a vast range of genital formations. Between their legs are tissue structures that vary along a continuum, from clitorises with a vulva through all possible combinations and gradations to penises with scrotal sac. These creatures live with an understanding that their genitals all developed prenatally from exactly the same little nub of embryonic tissue called a genital tubercle, which grew and developed under the influence of varying amounts of the hormone androgen. These creatures honor and respect everyone's natural-born genitalia –including what we would describe as a microphallus or a clitoris several inches long. What these creatures find amazing and precious is that because everyone's genitals stem from th same embryonic tissue, the nerves inside all their genitals got wired very much alike, so these nerves of touch just go crazy upon contact in a way that resonates completely between them. "My gosh," they think, "you must feel something in your genital tubercle that intensely resembles what I'm feeling in my genital tubercle." Well, they don't think that in so many words; they're actually quite heavy into their feelings at that point; but they do feel very connected –throughout all their wondrous variety. I could go on. I could tell you about the variety of hormones that course through their bodies in countless different patterns and proportions, both before birth and throughout their lives –the hormones that we call "sex hormones" but that they call "individuality inducers." I could tell you how these creatures think about reproduction: For part of their lives, some of these creatures are quite capable of gestation, delivery, and lactation; and for part of their lives, some of them are quite capable of insemination; and for part or all of their lives, some of them are not capable of any of those things – so these creatures conclude that it would be silly to lock anyone into a lifelong category based on a capability variable that may or may not be utilized and that in any case changes over each lifetime in a fairly uncertain and idiosyncratic way. These creatures are not oblivious to reproduction; but nor do they spend their lives constructing a self-definition around their variable reproductive capacities. They don't have to, because what is truly unique about those creatures is that they are capable of having a sense of personal identity without struggling to fit into a group identity based on how they were born. These creatures are quite happy, actually. They don't worry about sorting /other/ creatures into categories, so they don't have to worry about whether they are measuring up to some category they themselves are supposed to belong to.

Although molecular biology was not born in 1953 with the discovery of the structure of DNA by Watson and Crick, its elucidation has provided the molecular biologist with tools and techniques that have propelled the science forward. All the information required to make a human being is contained in a single cell. The molecules comprising this fertilized egg will organize the development, sustain the life, allow for the reproduction of, and ultimately execute the demise of an individual. Molecular biology is the study of the way in which molecules function to organize life. Remarkably, the same molecules and principles lie at the heart of all the life sciences, as they control the fundamental machinery of cells. The field of molecular biology concerns macromolecules such as nucleic acids, proteins, carbohydrates, and fats, and their interrelationships, that are essential for life itself.

Trading reproduction for repair, the sirtuins order our bodies to “buckle down” in times of stress and protect us against the major diseases of aging: diabetes and heart disease, Alzheimer’s disease and osteoporosis, even cancer. They mute the chronic, overactive inflammation that drives diseases such as atherosclerosis, metabolic disorders, ulcerative colitis, arthritis, and asthma. They prevent cell death and boost mitochondria, the power packs of the cell. They go to battle with muscle wasting, osteoporosis, and macular degeneration. In studies on mice, activating the sirtuins can improve DNA repair, boost memory, increase exercise endurance, and help the mice stay thin, regardless of what they eat. These are not wild guesses as to their power; scientists have established all of this in peer-reviewed studies published in journals such as Nature, Cell, and Science.

This is the story of the cell. It is a chronicle of the discovery that all organisms, including humans, are made of these “elementary particles”. It’s a story of how cooperative, organised accumulations of these autonomous living units - tissues, organs, and organ systems - enable profound forms of physiology: immunity, reproduction, sentience, cognition, repair, and rejuvenation.

The job of mTOR is basically to balance an organism’s need to grow and reproduce against the availability of nutrients. When food is plentiful, mTOR is activated and the cell (or the organism) goes into growth mode, producing new proteins and undergoing cell division, as with the ultimate goal of reproduction. When nutrients are scarce, mTOR is suppressed and cells go into a kind of “recycling” mode, breaking down cellular components and generally cleaning house. Cell division and growth slow down or stop, and reproduction is put on hold to allow the organism to conserve energy.

Making a human always takes the same three ingredients— an egg cell, a sperm cell, and a uterus. But just how the ingredients come together is a fascinating tale.

You can think of the human body as a set of transportation systems . . . Our reproductive system is a series of tunnels and tubes that transport egg and sperm cells from where they are made to where they need to go to create a pregnancy.

Making a human always takes the same three ingredients—an egg cell, a sperm cell, and a uterus. But just how the ingredients come together is a fascinating tale. Sometimes the ingredients that created us come from the same people who are raising us. Other times, we don’t share genetics with the people responsible for our care, such as when we are raised by stepparents, adoptive parents, or foster parents. This is also often true when donors and surrogates are involved.

Making a human always takes the same three ingredients—an egg cell, a sperm cell, and a uterus. But just how the ingredients come together is a fascinating tale. With discoveries in science and medicine, we have insemination and IVF, along with sex, to bring babies into the world. Sometimes the ingredients that created us come from the same people who are raising us. Other times, we don’t share genetics with the people responsible for our care, such as when we are raised by stepparents, adoptive parents, or foster parents. This is also often true when donors and surrogates are involved

Mothers not only pass the harms of endocrine-disrupting chemicals on to their fetuses but on to even more distant generations. When a mother is exposed to EDCs, so too are her fetus's germ cells, which develop into eggs or sperm. "It's thought that during that exposure, the chemical can target those germ cells and do what we call reprogramming, or making epigenetic changes," says Flaws. "That can be a permanent change that gets carried through generations, because those germ cells will eventually be used to make the next generation, and those fetuses will have abnormal germ cells that would then go on to make the next generation." In the mid-20th century, scientists documented this in women who took a synthetic form of estrogen, called diethylstilbestrol or DES, to prevent miscarriages.? The drug worked as intended, and the women gave birth to healthy babies. But once some of those children hit puberty, the girls developed vaginal and breast cancer. The boys developed testicular cancer, and some suffered abnormal development of the penis. Scientists called them DES daughters and sons. "When those DES daughters and sons had children, we now have DES granddaughters and grandsons, and a lot of them have increased risk of those same cancers and reproductive problems," says Flaws. "Even though it was their great-grandmother that took DES and they don't have any DES in their system-their germ cells have been reprogramming, and they're passing down some of these disease traits." And now toxicologists are gathering evidence that mothers are passing microplastics and nanoplastics complete with EDCs and other toxic substances- to their fetuses. In 2021, scientists announced that they'd found microplastics in human placentas for the first time, both on the fetal side and maternal side.Later that year, another team of researchers found the same, and they also tested meconium-a newborn's first feces and discovered microplastic there too. Children are consuming microplastics, then, before they're even born.

They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young. Trading reproduction for repair, the sirtuins order our bodies to “buckle down” in times of stress and protect us against the major diseases of aging: diabetes and heart disease, Alzheimer’s disease and osteoporosis, even cancer. They mute the chronic, overactive inflammation that drives diseases such as atherosclerosis, metabolic disorders, ulcerative colitis, arthritis, and asthma. They prevent cell death and boost mitochondria, the power packs of the cell. They go to battle with muscle wasting, osteoporosis, and macular degeneration. In studies on mice, activating the sirtuins can improve DNA repair, boost memory, increase exercise endurance, and help the mice stay thin, regardless of what they eat. These are not wild guesses as to their power; scientists have established all of this in peer-reviewed studies published in journals such as Nature, Cell, and Science.

Commercial polyunsaturated oils, such as soy oil, safflower oil, corn oil, cottonseed oil and canola oil, create serious imbalances on the cellular level. They are invariably rancid and a source of cancer-causing free radicals. Furthermore, they are loaded with hormone-like chemicals. The scientific literature indicates that overconsumption of polyunsaturated oils is especially damaging to the reproductive organs like the breasts. Even worse, most of the vegetables oils in our food come in the form of partially hydrogenated vegetable oils. When these altered fats are built into the cell membranes, they inhibit thousands of chemical reactions on the cellular level. Several major studies have definitely correlated consumption of partially hydrogenated vegetable oils with increased breast cancer but this fact is rarely mentioned, even in books that espouse alternative treatments to breast cancer.

The infected human hosts were not producing viral material as much as before. The cells were wearing out and some had stopped manufacturing the virus. Newer victims were needed to continue the reproductive cycle of the virus.

To produce Dolly, researchers at the Roslin Institute in Scotland used the DNA from just one cell from a mammary gland of her mother. A cell that forms the body of an organism is called a somatic cell. Most of your cells are somatic; the only exceptions are stem cells and reproductive cells. They say that Dolly the sheep was named for Dolly Parton, who along with a wonderful voice and excellent musical artistry has memorable mammary glands. (I am not kidding; that’s really what the Roslin scientists told reporters.)

Each grain of pollen may be likened to a sort of box. Inside are the plant's reproductive cells. It is essential for these cells to be well concealed to protect their life and keep them safe from external dangers. For this reason the structure of the box is very strong. The box is surrounded by a wall called the "sporoderm." The outermost layer of this wall, called exine, is the most resistant material known in the organic world, and its chemical make-up has not yet been fully analysed. This material is generally very resistant to damage from acids or enzymes. It is f u r t h e r m o re unaffected by high temperature and pre s s u re. As we have seen, very detailed precautions have been taken to protect the pollen, which is essential for the continued existence of plants. The grains have been very specially wrapped up. Thanks to this, whatever method the pollen is dispersed by, it can remain alive even miles away from the p a rent plant. Besides the fact that pollen grains are coated with a very resistant material, they are also dispersed in very large numbers, which guarantees the multiplication of that plant.

cell, for example, has about 2 m of DNA—a length about 250,000 times greater than the cell’s diameter. Yet before the cell can divide to form genetically identical daughter cells, all of this DNA must be copied, or replicated, and then the two copies must be separated so that each daughter cell ends up with a complete genome. The replication and distribution of so much DNA is manageable because the DNA molecules are packaged into structures called chromosomes, so named because they take up certain dyes used in microscopy (from the Greek chroma, color, and soma, body) (Figure 12.3). Each eukaryotic chromosome consists of one very long, linear DNA molecule associated with many proteins (see Figure 6.9). The DNA molecule carries several hundred to a few thousand genes, the units of information that specify an organism’s inherited traits. The associated proteins maintain the structure of the chromosome and help control the activity of the genes. Together, the entire complex of DNA and proteins that is the building material of chromosomes is referred to as chromatin. As you will soon see, the chromatin of a chromosome varies in its degree of condensation during the process of cell division. Every eukaryotic species has a characteristic number of chromosomes in each cell nucleus. For example, the nuclei of human somatic cells (all body cells except the reproductive cells) each contain 46 chromosomes, made up of two sets of 23, one set inherited from each parent. Reproductive cells, or gametes—sperm and eggs—have half as many chromosomes as somatic cells, or one set of 23 chromosomes in humans. The Figure 12.4 A highly condensed, duplicated human chromosome (SEM). Circle one sister chromatid of the chromosome in this micrograph. DRAW IT Sister chromatids Centromere 0.5μm number of chromosomes in somatic cells varies widely among species: 18 in cabbage plants, 48 in chimpanzees, 56 in elephants, 90 in hedgehogs, and 148 in one species of alga. We’ll now consider how these chromosomes behave during cell division. Distribution of Chromosomes During Eukaryotic Cell Division When a cell is not dividing, and even as it replicates its DNA in preparation for cell division, each chromosome is in the form of a long, thin chromatin fiber. After DNA replication, however, the chromosomes condense as a part of cell division: Each chromatin fiber becomes densely coiled and folded, making the chromosomes much shorter and so thick that we can see them with a light microscope. Each duplicated chromosome has two sister chromatids, which are joined copies of the original chromosome (Figure 12.4). The two chromatids, each containing an identical DNA molecule, are initially attached all along their lengths by protein complexes called cohesins; this attachment is known as sister chromatid cohesion. Each sister chromatid has a centromere, a region containing

The most important surviving relics of the primitive plants are mosses and ferns, which give us a clue to how ancient plants solved the problem of reproduction. They developed spores, or microscopic cells, which fell into the water, germinated, and formed male and female sex organisms that combined to create a new plant. Spores

one of the key hallmarks of aging is the accumulation of senescent cells. These are cells that have permanently ceased reproduction. Young human cells taken out of the body and grown in a petri dish divide about forty to sixty times until their telomeres become critically short, a point discovered by the anatomist Leonard Hayflick that we now call the Hayflick limit. Although the enzyme known as telomerase can extend telomeres—the discovery of which afforded Elizabeth Blackburn, Carol Greider, and Jack Szostak a Nobel Prize in 2009—it is switched off to protect us from cancer, except in stem cells. In 1997, it was a remarkable finding that if you put telomerase into cultured skin cells, they don’t ever senesce.

the disposable soma hypothesis posits that an organism with limited resources must apportion them between investing in early growth and reproduction and prolonging life by continuously repairing wear and tear in the cell.

A gene segment has no more need of an imaginary mediation in order to reproduce than does an earthworm, any segment of which can reproduce autonomously as an entire worm. Any cell of an American chief executive officer likewise suffices to produce a new chief executive officer. Similarly, any portion of a hologram may become the matrix of a new complete hologram: each discrete portion of the original hologram contains all the information needed for reproduction (though a slight loss of definition may occur). This is how the totality is eliminated. If all information is contained in each of its parts, the whole loses its significance. This means the end of the body also, the end of that unique object which we call the body, whose secret is precisely that it cannot be broken down into an accumulation of cells because it is an indivisible configuration - as witness the very fact that it is sexed. Paradoxically, cloning is destined to continue producing sexed beings indefinitely - clones must, of course, remain identical to their model - even as it turns sex itself into a useless function; not that sex was ever a function: on the contrary, it is what makes a body a body, something which transcends all that body's diverse functions. Sex (or death) is something that transcends the entirety of the information that can be collected concerning a given body. The genetic formula, by contrast, contains all such information, but cannot transcend it. It must therefore find its own autonomous path to reproduction, independently of sexuality and death.

There are cells throughout the body in specialised tissues with the beautiful name syncytium. They have multiple nuclei, formed when cells fuse with each other, which happens in the development of some muscle tissue, bone and heart cells. Syncytium in the placenta make up a highly specialised and essential tissue with the even more beautiful name syncytiotrophoblast. These are the spindly fingers from the growing placenta that invade the wall of the uterus and provide the interface between the mother and embryo, where liquids, waste and nutrients are exchanged. It’s also a tissue that suppresses the immune system of the mother, to stop her body automatically rejecting the growing child as an alien presence. These cells are at the junction of human reproduction, where one life is giving rise to the next. The genes that drive those placental cells to form are not human at all. Primates acquired them from a virus around forty-five million years ago;

Cancer, we have discovered, is stitched into our genome. Oncogenes arise from mutations in essential genes that regulate the growth of cells. Mutations accumulate in these genes when DNA is damaged by carcinogens, but also by seemingly random errors in copying genes when cells divide. The former might be preventable, but the latter is endogenous. Cancer is a flaw in our growth, but this flaw is deeply entrenched in ourselves. We can rid ourselves of cancer, then, only as much as we can rid ourselves of the processes in out physiology that depend on growth-aging, regeneration, healing, reproduction.

Genetically Modified Food produce proteins that the DNA does not recognise and so is unable to use these proteins in the reproduction of a new cell. The result is mutated cells.

The job of mTOR is basically to balance an organism’s need to grow and reproduce against the availability of nutrients. When food is plentiful, mTOR is activated and the cell (or the organism) goes into growth mode, producing new proteins and undergoing cell division, as with the ultimate goal of reproduction. When nutrients are scarce, mTOR is suppressed and cells go into a kind of “recycling” mode, breaking down cellular components and generally cleaning house.

It’s about those longevity genes AMPK and mTOR, which are important nutrient sensors. mTOR controls a number of cell functions, including cell growth and cell proliferation. For younger people who are growing or whose bodies are in reproductive mode, mTOR has many benefits. But when we get older, we don’t want to encourage cell proliferation (cancer is cell proliferation).

This much is undeniably true: we’ve thrown open the black box of the cell. To snap the lid shut now might be to foreclose the possibility of a magnificent future. To keep it jammed open without guidelines and rules would be to assume that we’ve reached some tacit global agreement about what is permissible and impermissible in the manipulation of human reproduction and development—which, assuredly, we have not.....The arguments won’t be resolved easily, for they impinge not just on the fundamental features of cells, but also on the fundamental features of humans. The only way to find a reasonable answer, or even a compromise, lies in a continuous engagement with evolving debate about the limits of scientific intervention, and the advancing front of cellular technologies. Every human is a stakeholder in this debate. It involves the one, the many, and the “many many.

Ancestors are typically thought of as the humans who came before us, our bloodline, or inherited bloodline. But consider that your life is a product of all evolution that led to you being here: the hominids, small furry mammals, reptiles, aquatic creatures, pools of algae, microbes—an uninterrupted line of reproduction and evolution that started with some amino acids in a pool of water and a strike of lightning. Even if you’re an ardent atheist, when you look through the billions of years that have led to you, made of trillions of cells and about 8.5 octillion atoms

...we might try to assuage our loneliness and fears by sleeping with partners we don't love or respect -- sometimes men who won't even remember our names -- as we use sex addictively to fill the emotional hole. But we never walk away from sex Scott free. Sex is more personal to us than to men, and there's a reason for that. The results of preliminary research suggests that when we have orgasms, our bodies release oxytocin, the same chemical that's produced during breast-feeding, and that heightens feelings of bonding. As [Niravi] Payne explains in The Language of Fertility, which is coauthored with Brenda Richardson, her work is based on research that validates thoughts and beliefs can affect functioning in cells, tissues and organs. In recent decades, scientists have learned that much of human perception is based not on information flowing into the brain from the external world, but on what the brain based on previous experience, expects to happen next. That means if we unconsciously believe that sex is "shameful" or something to be feared, that belief can be reflected in our reproductive organs by throwing our hormonal functioning, which regulates pregnancy, or in our immune system, which governs our ability to maintain a pregnancy, or even in our menstrual flow, which if malfunctioning can lead to fibroid tumors. Like all feelings, sexual feelings are energy, and when energy is suppressed, it builds and burst out in destructive ways. Clinical psychologist Darlene Powell Hopson has said she teaches her clients an invocation that in, part, she learned from fellow author Iyanla Vanzant: 'Dear God, I love you and being your child. You made me a sexual being and I want to experience closeness and fulfillment with my partner. My soul yearns for the pleasure and satisfaction of being spiritually and physically intimate with my partner....Please continue to remain with me and in me, forever.

If you have a preimplantation embryo in the early stages of development and split it, let us say into four clumps of cells, each one of these four clumps constitutes a new embryo which is viable and could be implanted with the reasonable expectation of successful development into adulthood (given the dramatic wastage rate of embryos in all human reproduction, see below). Each clump is the clone or identical “twin” of any of the others and comes into being not through conception but because of the division of the early cell mass. Moreover, these four clumps can be recombined into one embryo again. This creates a situation where, without the destruction of a single human cell, one human life, if that is what it is, can be split into four and can be recombined again into one. Did “life” in such a case begin as an individual, become four individuals and then turn into a singleton again? We should note that whatever our answer to this question, all this occurs without the creation of extra matter and without the destruction of a single cell.

Now Kito saw it. The mass wasn’t homogenous at all; it was composed of endless cells, each remarkably similar to the mosquitoes of the old world. The mass of mosquitoes reared up, readying to strike the men and consume them whole. The mass lashed finally, but it didn’t go for the men. It was heading toward the other three, maybe for an easy meal. The mass grew in density, then pinched itself off, part of it continuing toward their dead crewmates, the other part of it remaining inside the room with the men. “Kito-kun!” Kito didn’t hear her in his head this time; her voice had been real. “Maggie?!” Hemmler gasped. “I…I hear you, baby! I hear you!” The mass. Kito concluded that it was tailoring and changing itself to the specifics of each man’s mind. Kito heard it as Yui, and Hemmler heard Maggie. Was it already inside their heads? “Kito-kun!” Kito tried to hear her voice come from inside him, but the Yui in his memories was silent. There was only the voice coming from outside his own head–coming from the mosquito mass. “Kito-kun!” “Yes, Maggie! I’m here, baby! I’m here!” Hemmler shouted, a maniacal smile smeared across his face. The mass began taking shape, molding into something coherent. It grew limbs, a head, fingers and toes. It grew skin and body hair. Its formless face became eyes and nose and forehead and smile. Yui looked upon Kito Tanaka with giddy delight–a perfect reproduction down to the slight slant at the corner of her mouth. “It’s me, Kito-kun…” Yui breathed. Her naked body seemed like the only real thing in all the universe.

In this vision, the worlds is conceived as multiple and performative, i.e. shaped through practices, as different from a single pre-existing reality. This is why, for Bruno Latour, politics should become material, a Dingpolitik revolving around things and issues of concern, rather than around values and beliefs. Stem cells, mobile phones, genetically modified organisms, pathogens, new infrastructure and new reproductive technologies brings concerned publics into being that create diverse forms of knowledge about these matters and diverse forms of action - beyond institutions, political interests or ideologies that delimit the traditional domain of politics. Whether it is called ontological politics, Dingpolitik or cosmopolitics, this form of politics recognizes the vital role of nom-humans, in concrete situations, co-creating diverse forms of knowledge that need to be acknowledged and incorporated rather than silenced. Particular attention has gone to that most central organization of all for political geographers: the state. Instead of conceiving the state as a unified actor, it should be approached as an assemblage, which makes heterogenous points of order - geographic, ethnic, linguistic, moral, economic, technological particularities - resonate together. As such, the state is an effect rather than the origin of power, and one should focus on reconstructing the socio-material basis of its functioning. The concept of assemblage questions the naturalization of hegemonic assemblages and renders them open to political challenge by exposing their contingency.

A tree starts out as we do, as the union of two haploid gametes, the egg and the sperm. Cells divide again and again to become embryos. An infinitesimally small number of embryos become seedlings, and out of these, a tiny subset become trees. Time may stand still for decades in some seeds that enter dormancy until conditions for growth become suitable. Time may stop for decades as the seedling exists in the shade, garnering just enough energy for survival but not enough for growth. Time speeds up as sunlight is reached and the tree explodes in sudden growth and then proceeds along its trajectory to reproduction, senescence, and death. In some trees, like the gray birch and balsam fir, maximum life span is usually shorter than our own. In many others it is close to ours, while in a few trees, including the bristlecone pines, a life span of four thousand years is not impossible. Bristlecone pines grow extremely slowly because they live in a cold climate (the White Mountains of California) and because they have little water and few nutrients. They nevertheless stay a step or two ahead of decay and death because the climate also dries their deadwood. It takes them thousands of years to experience the growth, and life, that a white pine in Maine experiences in two hundred summers. Trees must be growing to be alive, but different species grow, and therefore live, at very different rates. Thus, even to a tree, both time and life are relative.

To begin the ending, we must end the beginning. Prevention will be the only compassionate, universally applicable cure. It is not prevention through lifestyle changes. Individuals with pristine eating and exercising habits get cancer because cancer-causing mutations accumulate as natural consequences of reproduction and aging of cells. The new strategy must go beyond early detection as practiced currently through mammograms and other routine screening tests. The prevention I am talking about is through identification and eradication of transformed cancerous cells at their inception, before they have had a chance to organize into a bona fide malignant, incurable disease. This may seem an unattainable, utopian dream, but it is achievable in a reasonable time. We are already using sophisticated technology to detect the residues of disease that linger after treatment, the last cancer cell. Can we not reverse the order of things and use the tests to detect the first?

1 an oval or round object laid by a female bird, reptile, fish, or invertebrate, usually containing a developing embryo. The eggs of birds are enclosed in a chalky shell, while those of reptiles are in a leathery membrane. an infertile bird's egg, especially one from a chicken, used for food. a thing resembling a bird's egg in shape: chocolate eggs. 2 [BIOLOGY] the female reproductive cell in animals and plants; an ovum. 3 [ARCHITECTURE] a decorative oval moulding, used alternately with triangular shapes: [as modifier] egg and dart moulding. 4 [with adj.] INFORMAL, DATED a person of a specified kind: the biography portrays him as a thoroughly bad egg. don't put all your eggs in one basket PROVERB don't risk everything on the success of one venture. go suck an egg [as imperative] NORTH AMERICAN INFORMAL used as an expression of anger or scorn. kill the goose that lays the golden eggs destroy a reliable and valuable source of income. [ with allusion to one of Aesop's fables.] lay an egg NORTH AMERICAN INFORMAL be completely unsuccessful. with egg on one's face INFORMAL appearing foolish or ridiculous: don't underestimate this team, or you'll be left with egg on your face. eggless adj. Middle English (superseding earlier ey, from Old English g): from Old Norse. egg2

There is a close connection between the key concept of the genetic code and the pathology of cancer. Cancer implies an infinite proliferation of a basic cell in complete disregard of the laws governing the organism as a whole. Similarly, in cloning, all obstacles to the extension of the reign of the Same are removed; nothing inhibits the proliferation of a single matrix. Formerly sexual reproduction constituted a barrier, but now at last it has become possible to isolate the genetic matrix of identity; consequently it will be possible to eliminate all the differences that have hitherto made individuals charming in their unpredictability.

Human Cloning: The Least Interesting Application of Cloning Technology One of the most powerful methods of applying life’s machinery involves harnessing biology’s own reproductive mechanisms in the form of cloning. Cloning will be a key technology—not for cloning actual humans but for life-extension purposes, in the form of “therapeutic cloning.” This process creates new tissues with “young” telomere-extended and DNA-corrected cells to replace without surgery defective tissues or organs. All responsible ethicists, including myself, consider human cloning at the present time to be unethical. The reasons, however, for me have little to do with the slippery-slope issues of manipulating human life. Rather, the technology today simply does not yet work reliably. The current technique of fusing a cell nucleus from a donor to an egg cell using an electric spark simply causes a high level of genetic errors.57 This is the primary reason that most of the fetuses created by this method do not make it to term. Even those that do make it have genetic defects. Dolly the Sheep developed an obesity problem in adulthood, and the majority of cloned animals produced thus far have had unpredictable health problems.58

Viruses spend virtually all of their time and energy replicating themselves inside a host cell. In fact, the singular goal of a virus is to make more viruses. A drug that interferes with a virus’s ability to replicate itself will neutralize it. Chemically speaking, HCQ acts as the doorman to the cell, allowing zinc to march in behind it, and it is actually the zinc which halts the viral reproduction. Zinc jams the genetic photocopier, to be sure, but HCQ enables zinc to get inside the cell in the first place.

Sets of three deoxyribonucleic acids in a specific order encode a specific amino acid, and the proteins are manufactured on those very old nanomachines, the ribosomes. The proteins are themselves used to make the nanomachines that allow the organism to generate energy and reproduce. The reproduction of cells is dependent on replication of the genes, and the replication of genes is dependent on the ability of the organism to generate energy, survive, and grow.

estrogen tells the liver habitually to favor the production of HDL over that of low-density lipoprotein. (Intense exercise can have a similarly promotional effect on the liver’s outlay of HDL; the rigors of chronic activity inspire the same anabolic spirit that reproduction does, the same need to scavenge available blood lipids for the sake of creating new cells.)

Our first chakra is called the Mooladhara which is found under the spinal cord. This core also known as the root chakra is ruled by Mars, who is also the creator of the sign Aries. The chakra of mooladhara stands for innocence, honesty, pure childlike happiness, knowledge, sense of direction and a strong connection with earth and creation. This brings us strength and decisiveness in our action if this chakra is high within us, the ability to find the best direction in life to make the right decisions. Mars represents physical strength and behavior amicable and kind among planets. Mars ' strength is strong, ordinary and sometimes instinctive. With positive Mars energy our action carries physical dynamism and courage. Thanks to this energy, we live each day with a child's enthusiasm and a fresh desire to discover life. In astrology, Mars rules the sexual energy of a person. Mars that has been badly affected takes a person to extremes. Likewise, the Mooladhara chakra controls the reproductive organs, but due to hardships and things not harmless, its responsiveness is weakened. We will sense the goodness inside us and want to live as our first chakra is stronger accordingly. •       Our second chakra, the Swadisthan, is located in the area of our abdomen and is governed by Mercury. Mercury governs in astrology the signs of Gemini and Virgo. This chakra's most important function is to break down fat cells in the stomach and provide the energy needed to renew white and gray cells within the brain. It also reinforces our capacity to think. This chakra supports all areas of our sense of esthetics and creativity. The ability to easily comprehend, and come up with practical solutions to our life and knowledge issues all come from this chakra. Mercury is an astrological representation of intelligence, mind and creativity. With this chakra pure knowledge flows into our being out of the Greater Consciousness. Mercury acts as a bridge between mind, spirit and matter. It rules science and the fine arts. Strong Mercury energy can connect even the most complex thoughts and difficult concepts in the birth chart. People who are under this planet's influence experience constant mental activity. This could produce an easily angry and impatient nature. The result is the same when we make too much use of the energy of our second chakra. A balanced Swadisthan provides a person with clear attention to making healthy decisions.

Probiotics are one of the best supplements you can take to avoid an intestinal imbalance. They strengthen the intestinal walls and manufacture vital nutrients. They also help the body to use nutrients and fight harmful microbes in the GI tract. Your body actually contains about ten times as many probiotic bacteria cells as it does human cells! You simply couldn't survive without these little creatures. Probiotics protect us from a number of health problems, including food allergies and skin problems. Probiotics also play a key role in the female reproductive system. Like the GI tract, the vagina contains and relies on a delicate ecosystem for optimal health. The Lactobacillus strains that populate the walls of the vagina make the environment too acidic for most intruders, thus protecting the vagina and the womb from infection. Just like the GI tract, however, this ecosystem can easily become disrupted by the exact same causes: antibiotics and stress. Spermicides and birth control pills can also cause an imbalance. Imbalances can usually be remedied with therapeutic doses of Lactobacillus acidophilus. When you buy probiotic supplements, it's important to know which strains of probiotic bacteria are in the supplement. Each strain and substrain offers its own unique benefits. The Lactobacillus and Bifidobacterium strains are found naturally in the human GI tract and offer countless health benefits. They're the most prevalent strains you'll find in supplements. Lactobacillus GG, sold as Culturelle, is the best studied. Bacillus subtilis is a wonderfully beneficial probiotic that does not occur naturally in humans but is found in many probiotic supplements. It's excellent at killing pathogens and unwanted microorganisms. If B. subtilis is on the ingredients list of your probiotic supplement, you have a gentle friend offering powerful protection. Probiotic supplements come in capsules and powders. They're alive yet dormant when you get them in this form and become active when exposed to warmth and moisture inside your body. Either form is fine, but it's critical to take them on an empty stomach (when your stomach acid levels are low). Even though they can live in the intestines, most probiotics don't survive stomach acid. Enteric-coated capsules help, too. During pregnancy, the advantage to taking probiotic supplements instead of fermented probiotic sources like kombucha, kefir, or yogurt is that the exact strains you're getting are tightly controlled. The cultures used in fermented foods aren't always tightly controlled, so you run the risk of ingesting organisms like yeasts, which produce toxins.

Leptin is a hormone that is secreted by fat cells in white adipose tissue (figure 1). Leptin was found to be a signal to the brain, having a primary influence on body weight. It was also discovered to be involved with insulin, cardiovascular health, reproductive function, sex hormones, immune function, adrenal function, stress, thyroid function, bone health, cancer, and inflammation. Indeed, it has a major determining role in many aspects of healthy function. When leptin falls out of natural balance and loses its ability to communicate efficiently, health problems follow. Thus, the concept of fat as a storage place has been transformed to fat as a major endocrine organ, like the thyroid gland, adrenal glands, and sex glands.19