Brain Stimulating Quotes

You were designed to be very smart, Max,' she told me. 'We electrically stimulated your synaptic nerve endings while your brain was developing.' (The director) And yet I still can't program my DVD player,' I said." (Max)

He thinks he's happy but it's just a nerve cell in his brain that's getting too much stimulation or too little stimulation.

- My instructors in science and technology have taught us about how the brain works. It's full of electrical impulses. It's like a computer. If you stimulate one part of the brain with an electrode, it... - They know nothing.

Whenever you squander attention on something that doesn’t put your brain through its paces and stimulate change, your mind stagnates a little and life feels dull.

Books are not something that you just read words in. They're also a tool to adjust your senses. When I'm not feeling well there are times that I can't take in what I read. When that happens, I try to think about what could be hindering my reading. There are books that I can take in smoothly even when I'm not feeling well. I try to think why. It might be something like mental tuning. What's important when you tune is the feeling of the paper that you're touching with your fingers and the momentary stimulation your brain receives when you turn pages...

Given her deafness, the auditory part of the brain, deprived of its usual input, had started to generate a spontaneous activity of its own, and this took the form of musical hallucinations, mostly musical memories from her earlier life. The brain needed to stay incessantly active, and if it was not getting its usual stimulation..., it would create its own stimulation in the form of hallucinations.

Researchers would eventually discover that autistic people stim to reduce anxiety—and also simply because it feels good. In fact, harmless forms of self-stimulation (like flapping and fidgeting) may facilitate learning by freeing up executive-functioning resources in the brain that would otherwise be devoted to suppressing them.

Multitasking has been found to increase the production of the stress hormone cortisol as well as the fight-or-flight hormone adrenaline, which can overstimulate your brain and cause mental fog or scrambled thinking. Multitasking creates a dopamine-addiction feedback loop, effectively rewarding the brain for losing focus and for constantly searching for external stimulation. To make matters worse, the prefrontal cortex has a novelty bias, meaning that its attention can be easily hijacked by something new—the proverbial shiny objects

A powerful AI system tasked with ensuring your safety might imprison you at home. If you asked for happiness, it might hook you up to a life support and ceaselessly stimulate your brain's pleasure centers. If you don't provide the AI with a very big library of preferred behaviors or an ironclad means for it to deduce what behavior you prefer, you'll be stuck with whatever it comes up with. And since it's a highly complex system, you may never understand it well enough to make sure you've got it right.

From dopamine’s point of view, having things is uninteresting. It’s only getting things that matters. If you live under a bridge, dopamine makes you want a tent. If you live in a tent, dopamine makes you want a house. If you live in the most expensive mansion in the world, dopamine makes you want a castle on the moon. Dopamine has no standard for good, and seeks no finish line. The dopamine circuits in the brain can be stimulated only by the possibility of whatever is shiny and new, never mind how perfect things are at the moment. The dopamine motto is “More.

Your body produces some chemicals that stimulate some nerves that send a signal to your brain saying 'Oh my God, I am going to die,' and that's how you get pain.

You hate him worse than me, you viper,’ he whispered as the stimulant cleared his brain. ‘Aye, lord, but here’s the oddity of it - I love him too.’ Morgan replied, her eyes void of all emotion.

The mind and body are linked together in a meshwork of oxygen, nutrients, hormones, and neuron health. Physical exercise drives that meshwork, stimulating the brain and freeing one’s intellect.

Any form of negative rumination—for example, worrying about your financial future or health—will stimulate the release of destructive neurochemicals.

The British researchers found that it takes a lot of money to beat out the most rewarding smiles we see. In the case of this study, it took up to 16,000 pounds sterling in cash to generate the same level of brain stimulation as one smile! This

Researchers have known for some time now that the cornerstone of all degenerative conditions, including brain disorders, is inflammation. But what they didn’t have documented until now are the instigators of that inflammation—the first missteps that prompt this deadly reaction. And what they are finding is that gluten, and a high-carbohydrate diet for that matter, are among the most prominent stimulators of inflammatory pathways that reach the brain.

The bottom line is this: environmental toxins are all around us, and they stimulate the production of free radicals, which can cause axidative damage to any kind of cell, be it muscle, nerve, liver, kidney,, heart, brain, and so on, and cause autoimmune disease.

When we constantly fill up all our "empty" time with stimulation in the form of electronic devices, games, and distractions, our brains become disengaged and the thinking process is effectively halted. We never get to hear our own inner voice-we don't develop a relationship with ourselves and our minds. We don't get to know who we are because we're not listening.

Testosterone also increases confidence and optimism, while decreasing fear and anxiety.5 This explains the “winner” effect in lab animals, where winning a fight increases an animal’s willingness to participate in, and its success in, another such interaction. Part of the increased success probably reflects the fact that winning stimulates testosterone secretion, which increases glucose delivery and metabolism in the animal’s muscles and makes his pheromones smell scarier. Moreover, winning increases the number of testosterone receptors in the bed nucleus of the stria terminalis (the way station through which the amygdala communicates with the rest of the brain), increasing its sensitivity to the hormone. Success in everything from athletics to chess to the stock

At the most elementary level of information processing, stimulation is energy, and my brain needed to be protected, and isolated from obnoxious sensory stimulation, which it perceived as noise.

Pornography causes release of adrenaline from an area in the brain called the locus coeruleus, and this makes the heart race in those who view, or even anticipate, viewing pornography. The sexual pleasure of pornography may be partially caused by release of dopamine from the ventral tegmental area, and this stimulates the nucleus accumbens, one of the key pleasure centers of the brain.

As we age and plasticity declines, it becomes increasingly difficult for us to change in response to the world, even if we want to. We find familiar types of stimulation pleasurable; we seek out like-minded individuals to associate with, and research shows we tend to ignore or forget, or attempt to discredit, information that does not match our beliefs, or perception of the world, because it is very distressing and difficult to think and perceive in unfamiliar ways. Increasingly the aging individual acts to preserve the structures within, and when there is a mismatch between his internal neurocognitive structures and the world, he seek to change the world. In small ways he begins to micromanage his environment, to control it, and make it familiar. But this process, writ large, often leads whole cultural groups to try to impose their view of the world on other cultures, and they often become violent, especially in the modern world, where globalization has brought different cultures closer together, exacerbating the problem. Wexler's point, then, is that much of the cross-cultural conflict we see is a product of the relative decrease in plasticity. One could add that totalitarian regimes seem to have an intuitive awareness that it becomes hard for people to change after a certain age, which is why so much effort is made to indoctrinate the young from an early age.

Pull up a weed from the wet soil of the drenched garden and smell the rich life the earthworm has left behind. Just a whiff of it will flood you with a feeling of well-being. The microbes in freshly turned soil stimulate serotonin production, working on the human brain the same way antidepressants do.

...ideas are definitely unstable, they not only CAN be misused, they invite misuse--and the better the idea the more volatile it is. That's because only the better ideas turn into dogma, and it is this process whereby a fresh, stimulating, humanly helpful idea is changed into robot dogma that is deadly. In terms of hazardous vectors released, the transformation of ideas into dogma rivals the transformation of hydrogen into helium, uranium into lead, or innocence into corruption. And it is nearly as relentless. The problem starts at the secondary level, not with the originator or developer of the idea but with the people who are attracted by it, who adopt it, who cling to it until their last nail breaks, and who invariably lack the overview, flexibility, imagination, and most importantly, sense of humor, to maintain it in the spirit in which it was hatched. Ideas are made by masters, dogma by disciples, and the Buddha is always killed on the road. There is a particularly unattractive and discouragingly common affliction called tunnel vision, which, for all the misery it causes, ought to top the job list at the World Health Organization. Tunnel vision is a disease in which perception is restricted by ignorance and distorted by vested interest. Tunnel vision is caused by an optic fungus that multiplies when the brain is less energetic than the ego. It is complicated by exposure to politics. When a good idea is run through the filters and compressors of ordinary tunnel vision, it not only comes out reduced in scale and value but in its new dogmatic configuration produces effects the opposite of those for which it originally was intended. That is how the loving ideas of Jesus Christ became the sinister cliches of Christianity. That is why virtually every revolution in history has failed: the oppressed, as soon as they seize power, turn into the oppressors, resorting to totalitarian tactics to "protect the revolution." That is why minorities seeking the abolition of prejudice become intolerant, minorities seeking peace become militant, minorities seeking equality become self-righteous, and minorities seeking liberation become hostile (a tight asshole being the first symptom of self-repression).

Like a bee in a flower bed, the human brain naturally flits from one thought to the next. In the high-speed workplace, where data and headlines come thick and fast, we are all under pressure to think quickly. Reaction, rather than reflection, is the order of the day. To make the most of our time, and to avoid boredom, we fill up every spare moment with mental stimulation…Keeping the mind active makes poor use of our most precious resource. True, the brain can work wonders in high gear. But it will do so much more if given the chance to slow down from time to time. Shifting the mind into lower gear can bring better health, inner calm, enhanced concentration and the ability to think more creatively.

If you stimulate seizures in an animal every day, the seizures eventually become automatic; the animal will go on having them once a day even if you withdraw the stimulation. In much the same way, the brain that has gone into depression a few times will continue to return to depression over and over. This suggests that depression, even if it is occasioned by external tragedy, ultimately changes the structure, as well as the biochemistry, of the brain.

Recent experiments in neuroscience support the view that it is our physical brain, following the known laws of science, that determines our actions, and not some agency that exists outside those laws. For example, a study of patients undergoing awake brain surgery found that by electrically stimulating the appropriate regions of the brain, one could create in the patient the desire to move the hand, arm or foot, or to move the lips and talk. It is hard to imagine how free will can operate if our behaviour is determined by physical law, so it seems that we are no more than biological machines and that free will is just an illusion.

The Emory University neuroscientists James Rilling and Gregory Berns found that helping people in need stimulates the same brain region as winning a prize or eating a delicious meal. We also know that depressed (and formerly depressed) people are more likely to see the world from others’ points of view and to experience compassion; conversely, high-empathy people are more likely than others to enjoy sad music.

Every time you take in the sense of feeling safe, satisfied, or connected, you stimulate responsive circuits in your brain.

By removing every object of attention that’s potentially more stimulating and attractive than what you intend to do, you give your brain no choice but to work on that task.

stimulation of the medial frontal cortex gives one the feeling of the urge to move

The very definition of an addictive drug is one that stimulates the mesolimbic pathway, but there are three general axioms in psychopharmacology that also apply to all drugs: 1. All drugs act by changing the rate of what is already going on. 2. All drugs have side effects. 3. The brain adapts to all drugs that affect it by counteracting the drug’s effects.

Building an Alzheimer’s-resistant brain through cognitive stimulation means learning to play piano, meeting new friends, traveling to a new city, or reading this book. You’re welcome.

. . . never seen him inspired by any more dangerous stimulant than strong coffee, of which he was very fond & of which [he] drank freely. MacIntosh says that the measure of a man's brain is the amount of coffee he can drink with impunity. SARAH HELEN WHITMAN (POE'S FIANCÉE) TO JOHN INGRAM DECEMBER 13, 1874

If you want to see philosophy in action, pay a visit to a robo-rat laboratory. A robo-rat is a run-ofthe-mill rat with a twist: scientists have implanted electrodes into the sensory and reward areas in the rat’s brain. This enables the scientists to manoeuvre the rat by remote control. After short training sessions, researchers have managed not only to make the rats turn left or right, but also to climb ladders, sniff around garbage piles, and do things that rats normally dislike, such as jumping from great heights. Armies and corporations show keen interest in the robo-rats, hoping they could prove useful in many tasks and situations. For example, robo-rats could help detect survivors trapped under collapsed buildings, locate bombs and booby traps, and map underground tunnels and caves. Animal-welfare activists have voiced concern about the suffering such experiments inflict on the rats. Professor Sanjiv Talwar of the State University of New York, one of the leading robo-rat researchers, has dismissed these concerns, arguing that the rats actually enjoy the experiments. After all, explains Talwar, the rats ‘work for pleasure’ and when the electrodes stimulate the reward centre in their brain, ‘the rat feels Nirvana’. To the best of our understanding, the rat doesn’t feel that somebody else controls her, and she doesn’t feel that she is being coerced to do something against her will. When Professor Talwar presses the remote control, the rat wants to move to the left, which is why she moves to the left. When the professor presses another switch, the rat wants to climb a ladder, which is why she climbs the ladder. After all, the rat’s desires are nothing but a pattern of firing neurons. What does it matter whether the neurons are firing because they are stimulated by other neurons, or because they are stimulated by transplanted electrodes connected to Professor Talwar’s remote control? If you asked the rat about it, she might well have told you, ‘Sure I have free will! Look, I want to turn left – and I turn left. I want to climb a ladder – and I climb a ladder. Doesn’t that prove that I have free will?

So, you wanna know what I want? I want it all. I want to be in love so much it hurts. The frissons. The pin pricks. The mind-blowing sex. The connection. And I want to be married with kids I adore and a husband who makes me feel safe, sexy, smart, secure, silly, serious, salacious, sinful, serene, satisfied. I want someone who makes me laugh until milk comes out of my nose (only I don’t drink milk). I want to finish someone’s sentences. I want to believe in someone, in something, in a future that’s not just about laundry and soccer practice and subdivisions and minivans and guilt-tripping grandparents. I want to make someone a better person. I want to be a good example. I want to love some kids into the world. I want someone who stimulates my brain as much as my body. I want to taste everything and go everywhere. I want to give and I want to get. I want too much and I want it all in one person.

Recovery through sleep isn’t going to happen if the majority of the components of your being aren’t getting enough stimulation or resistance to work against. Your brain may be tired after work, but if your body and emotions haven’t been challenged through the day, they’re going to keep irritating you even if you’re asleep. They don’t need rest; they need work for real recovery to take place.

The feelings of excitement, enthusiasm, and energy dissipate. Dopamine has shut down. Dopamine circuits don’t process experience in the real world, only imaginary future possibilities. For many people it’s a letdown. They’re so attached to dopaminergic stimulation that they flee the present and take refuge in the comfortable world of their own imagination. “What will we do tomorrow?” they ask themselves as they chew their food, oblivious to the fact that they’re not even noticing this meal they had so eagerly anticipated. To travel hopefully is better than to arrive is the motto of the dopamine enthusiast.

Between the stimulation received from the environment and our response, certain processes had to occur inside the brain, and cognitive researchers revealed the human mind to be a great interpreting machine that made patterns and created sense of the world outside, forming maps of reality.

The things most people need to learn in therapy are related to attachment, abandonment, love, and fear. We are trying to access basic emotional processes that are organized in primitive and early-developing parts of the brain. The language of these emotions is also very basic; it is the language of childhood. The more complex the language and ideas you bring into therapy, the more likely you are to stimulate your clients’ intellectualizing defenses.

Exercise has a direct brain connection, when you consider what it actually does. What we tend to overlook are the feedback loops that connect the brain to every cell in the body. Therefore when you throw a ball, run on a treadmill, or jog along the shore, billions of cells are "seeing" the outside world. The chemicals transmitted form the brain are acting the way sense organs do, making contact with the outside world and offering stimulation from that world. This is why the jump from being sedentary to doing a minimal amount of exercise - such as walking, light gardening, and climbing the stairs instead of taking the elevator - is so healthy. Your cells want to be part of the world.

Cynicism is popular because it stimulates the brain chemicals that make you feel good. It stimulates dopamine by making the world feel predictable. It triggers serotonin by making you feel superior to “the jerks.” It triggers oxytocin by telling you who to trust. You pay a high price for these moments, unfortunately, because cynicism keeps you focused on problems instead of opportunities.

As we age and plasticity declines, it becomes increasingly difficult for us to change in response to the world, even if we want to. We find familiar types of stimulation pleasurable; we seek out like-minded individuals to associate with, and research shows we tend to ignore or forget, or attempt to discredit, information that does not match our beliefs, or perception of the world, because it is very distressing and difficult to think and perceive in unfamiliar ways.

More recently, these electrodes have targeted a new area of the brain (called Brodmann’s area number 25) that is often overactive in depressed patients who do not respond to psychotherapy or drugs. Deep brain stimulation has given almost miraculous relief after decades of torment and agony for these long-suffering patients.

Talking to oneself is a recognized means to learn, in fact, self-speak may be the seed concept behind human consciousness. Private conversation that we hold with ourselves might represent the preeminent means to provoke the speaker into thinking (a form of cognitive auto-stimulation), modify behavior, and perhaps even amend the functional architecture of the plastic human brain. Writing out our private talks with oneself enables a person to “see” what they think, a process that invites reflection, ongoing thoughtful discourse with the self, and refinement of our thinking patterns and beliefs. Internal sotto voice conversations with our private-self provide several advantages, but most people find it difficult to maintain self-speak for an extended period. Internal dialogue must compete with external distractions. Writing allows a person to resume a personal dialogue where they left off before interrupted by outside stimuli. A written disquisition also provides a permanent record that a person can examine, amend, supplement, update, or reject.

Though introverts look calm on the surface, our brains are bubbling with activity, and thus we require less external stimulation than extroverts.

Minds were human (barely), but they were so much bigger than ordinary brains, they needed stimulation in order to keep from going completely insane.

Dopamine and constant stimulation can impair your ability to think long term

Surprise stimulates the brain, and research shows that people who do new things and visit new places—even something as modest as a trip to a new restaurant—tend to be happier.

Indeed, excessive stimulation seems to impede learning: a recent study found that people learn better after a quiet stroll through the woods than after a noisy walk down a city street. Another study, of 38,000 knowledge workers across different sectors, found that the simple act of being interrupted is one of the biggest barriers to productivity. Even multitasking, that prized feat of modern-day office warriors, turns out to be a myth. Scientists now know that the brain is incapable of paying attention to two things at the same time. What looks like multitasking is really switching back and forth between multiple tasks, which reduces productivity and increases mistakes by up to 50 percent.

There are already cardiac pacemakers that can sense the beat of the human heart; only when there is the slightest hint of fibrillation does the pacemaker stimulate the heart. This is a mild but very useful sort of machine intelligence. I cannot imagine the wearer of this device resenting its intelligence. I

This is what learning does. It gives us more things to think about so we have less time to get bored, depressed and under-stimulated. It builds on our existing knowledge and expands it. IT leads us to make more connections by linking together more neural pathways. It also connects our brains to other people's brains.

Reading allows us to traverse time, space, one’s own consciousness. It engages the mind like nothing else, stimulating every part of the brain and allowing the reader to experience everything as if they were truly there.

Experiencing empathy, the freedom to explore, trust, and insight can reset your default reactions to a more curious, tolerant, and confident stance. Because our brains are plastic, consistently positive experiences do stimulate existing neurons to adapt and connect in different pathways. Nurturing relationships help us grow psychologically and neurally in ways that are not possible in nonnurturing relationships. As adults, our most important opportunity for a nurturing relationship comes through committed partnership. It’s a breakthrough to realize that the purpose of committed relationship is not to be happy, but to heal. And then you will be happy!

Sex becomes less and less pleasurable in a relationship over time. Your brain gets habituated to the sensual stimulation from your specific partner as you are exposed to it repeatedly. It doesn’t mean that the love is gone from the relationship. Love still exists beyond the barriers of time, in the form of attachment, which becomes independent of sexual intimacy after the euphoric stage of mad love.

After he had sailed around the Mediterranean in 1869, Mark Twain said that travel was “fatal to prejudice, bigotry, and narrow-mindedness.” Neuroscientists have been trying for years to pin down what it is about travel that alters us, how it effects mental change. Neural pathways become ingrained, automatic, if they operate only by habit. They are highly attuned to alterations, to novelty. New sights, sounds, languages, tastes, smells stimulate different synapses in the brain, different message routes, different webs of connection, increasing our neuroplasticity. Our brains have evolved to notice differences in our environment: it’s how we’re alerted to predators, to potential danger. To be sensitive to change, then, is to ensure survival.

The neuroplastic brain evolved in ambulatory beings who ranged around the world, always having to explore unknown territories. In other words, the brain evolved to learn. As people become immobile, they see less, hear less, and process less new information, and their brains begin to atrophy from the lack of stimulation (unless they are fundamentally thinkers, and even then the neuroplastic systems require physical movement to generate new cells and nerve growth factor).

But the female mind has demonstrated a capacity for all the mental acquirements and achievements of men, and as generations ensue that capacity will be expanded; the average woman will be as well educated as the average man, and then better educated, for the dormant faculties of her brain will be stimulated to an activity that will be all the more intense and powerful because of centuries of repose. Woman will ignore precedent and startle civilization with their progress.

My favorite definition of fear is “False Expectations Appearing Real,” and when I allow myself to remember that all of my thoughts are merely fleeting physiology, I feel less moved when my story-teller goes haywire and my circuitry is triggered. At the same time, when I remember that I am at one with the universe, then the concept of fear loses its power. To help protect myself from having a trigger-happy anger or fear response, I take responsibility for what circuitry I purposely exercise and stimulate. In an attempt to diminish the power of my fear/anger response, I intentionally choose not to watch scary movies or hang out with people whose anger circuitry is easily set off. I consciously make choices that directly impact my circuitry. Since I like being joyful, I hang out with people who value my joy.

The complex tactile movement of writing by hand stimulates our mind more effectively than typing. It activates multiple regions of the brain simultaneously, thereby imprinting what we learn on a deeper level. As a result, we retain information longer than we would by tapping it into an app.18 In one study, college students who were asked to take lecture notes by hand tested better on average than those who had typed out their notes. They were also able to better retain this information long after the exam.

From dopamine’s point of view, having things is uninteresting. It’s only getting things that matters. If you live under a bridge, dopamine makes you want a tent. If you live in a tent, dopamine makes you want a house. If you live in the most expensive mansion in the world, dopamine makes you want a castle on the moon. Dopamine has no standard for good, and seeks no finish line. The dopamine circuits in the brain can be stimulated only by the possibility of whatever is shiny and new, never mind how perfect things are at the moment.

When you’re judging, you’re not listening. And if you’re not listening, you’re missing out on one of the best ways to stimulate your smart vagus pathway and turn down the volume of your stress-response system. But if you’re not judging, you can listen more and feel calmer, and this, in turn, will make interacting with others much easier and judging others less necessary.

Lithium regulates the proteins that control the body’s inner clock. This clock runs, oddly, on DNA, inside special neurons deep in the brain. Special proteins attach to people’s DNA each morning, and after a fixed time they degrade and fall off. Sunlight resets the proteins over and over, so they hold on much longer. In fact, the proteins fall off only after darkness falls—at which point the brain should “notice” the bare DNA and stop producing stimulants. This process goes awry in manic-depressives because the proteins, despite the lack of sunlight, remain bound fast to their DNA. Their brains don’t realize they should stop revving. Lithium helps cleave the proteins from DNA so people can wind down. Notice that sunlight still trumps lithium during the day and resets the proteins; it’s only when the sunlight goes away at night that lithium helps DNA shake free. Far from being sunshine in a pill, then, lithium acts as “anti-sunlight.” Neurologically, it undoes sunlight and thereby compresses the circadian clock back to twenty-four hours—preventing both the mania bubble from forming and the Black Tuesday crash into depression.

mental activity such as directing attention, actually shape the structure of the brain?” As we’ve seen, experience means neural firing. When neurons fire together, the genes in their nuclei—their master control centers—become activated and “express” themselves. Gene expression means that certain proteins are produced. These proteins then enable the synaptic linkages to be constructed anew or to be strengthened. Experience also stimulates the production of myelin, the fatty sheath around axons, resulting in as much as a hundredfold increase in the speed of conduction down the neuron’s length. And as we now know, experience can also stimulate neural stem cells to differentiate into wholly new neurons in the brain. This neurogenesis, along with synapse formation and myelin growth, can take place in response to experience throughout our lives. As discussed before, the capacity of the brain to change is called neuroplasticity We are now discovering how the careful focus of attention amplifies neuroplasticity by stimulating the release of neurochemicals that enhance the structural growth of synaptic linkages among the activated neurons.

I was diagnosed with ADHD in my mid fifties and I was given Ritalin and Dexedrine. These are stimulant medications. They elevate the level of a chemical called dopamine in the brain. And dopamine is the motivation chemical, so when you are more motivated you pay attention. Your mind won't be all over the place. So we elevate dopamine levels with stimulant drugs like Ritalin, Aderall, Dexedrine and so on. But what else elevates Dopamine levels? Well, all other stimulants do. What other stimulants? Cocaine, crystal meth, caffeine, nicotine, which is to say that a significant minority of people that use stimulants, illicit stimulants, you know what they are actually doing? They're self-medicating their ADHD or their depression or their anxiety. So on one level (and we have to go deeper that that), but on one level addictions are about self-medications. If you look at alcoholics in one study, 40% of male adult alcoholics met the diagnostic criteria for ADHD? Why? Because alcohol soothes the hyperactive brain. Cannabis does the same thing. And in studies of stimulant addicts, about 30% had ADHD prior to their drug use. What else do people self-medicate? Someone mentioned depression. So, if you have been treated for depression, as I have been, and you were given a SSRI medication, these medications elevate the level of another brain chemical called serotonin, which is implicated in mood regulation. What else elevates serotonin levels temporarily in the brain? Cocaine does. People use cocaine to self-medicate depression. People use alcohol, cannabis and opiates to self-medicate anxiety. Incidentally people also use gambling or shopping to self-medicate because these activities also elevate dopamine levels in the brain. There is no difference between one addiction and the other. They're just different targets, but the brain systems that are involved and the target chemicals are the same, no matter what the addiction. So people self-medicate anxiety, depression. People self-medicate bipolar disorder with alcohol. People self-medicate Post-Traumatic-Stress-Disorder. So, one way to understand addictions is that they're self-medicating. And that's important to understand because if you are working with people who are addicted it is really important to know what's going on in their lives and why are they doing this. So apart from the level of comfort and pain relief, there's usually something diagnosible that's there at the same time. And you have to pay attention to that. At least you have to talk about it.

People who live with ADHD are at high risk of addiction, especially adolescents, because of their poorly functioning frontal lobes. Years ago, when the illness was less well understood, doctors and parents were reluctant to give these vulnerable children addictive drugs such as Ritalin and amphetamine. It sounded reasonable: don’t give addictive substances to people at risk for addiction. But rigorous testing showed unambiguously that adolescents who were treated with stimulant drugs were less likely to develop addictions. In fact, those who started the drug at the youngest age and took the highest doses were the least likely to develop problems with illicit drugs. Here’s why: if you strengthen the dopamine control circuit, it’s a lot easier to make wise decisions. On the other hand, if effective treatment is withheld, the weakness of the control circuit is not corrected. The desire circuit acts unopposed, increasing the likelihood of high-risk, pleasure-seeking behavior.

Sleep hygiene is a set of practices sleep experts recommend to obtain quality rest on a daily basis. Recommendations include low levels of stimulation in the evening, exercise and exposure to lots of natural light during the day, banning electronics from the bedroom, and sticking to a regular sleep-wake schedule. Children and teens who are stressed tend to have poor sleep hygiene if left to their own devices.

Imagine a brain floating in a tank with millions and millions of electrodes attached to specific nerve centers. Now imagine these electrodes being selectively stimulated by a computer to cause the brain to believe that it was walking down Hollywood Boulevard chomping on a hamburger and checking out the chicks.

Now, if there was a technological foul-up, or if the tapes got jumbled, the brain would suddenly see Jesus Christ pass by down Hollywood Boulevard on his way to Golgotha, pursued by a crowd of angry people, being whipped along by seven Roman Centurions.

The brain would say, "Now hold on there!" And suddenly the entire image would go "pop" and disappear.

I've always had this funny feeling about reality. It just seems very feeble to me sometimes. It doesn't seem to have the substantiality that it's suppose to have.

Winning the love of a higher-status person is a widespread strategy for stimulating serotonin. Of course, we don’t consciously equate love with status. But when a highstatus person of the right gender notices you, your brain lights up. Your neurochemistry screams “Go toward this. It is very good for your survival. ” Even bonobos, the apes known for their sexual dynamism, compete vigorously for high-status partners

mothers suffered from major nausea and vomiting during pregnancy. When the children reached school age, 21 percent scored 130 or more points on a standard IQ test, a level considered gifted. If their mothers had no morning sickness, only 7 percent of kids did that well. The researchers have a theory—still to be proven—about why. Two hormones that stimulate a woman to vomit may also act like neural fertilizer for the developing brain.

Over the years, I've moved through alternating cycles of personal neglect and nourishment. Sometimes it's just easier to give in and allow my life to become utterly consumed by the menial and trivial than to justify or assert my individual needs. Then, disgusted with my malaise, I rise up, spurred to action by a resurgence of energy, determined to find new ways of incorporating creative expression into my life without upsetting the domestic applecart. Like a salmon's impulse to swim upstream, the urge to improve my mind and keep my brain stimulated with fresh experiences and challenges seems innate, almost primal. Struggling for my inner life, I know I must keep oxygen flowing through my intellectual gills or I will die. Pushing against stagnation and opposing currents, I swim for mental survival, obsessed with reaching some instinctual goal and preserving my sanity.

Reality, he wrote, “has to be funneled through the reducing valve of the brain and nervous system. What comes out at the other end is a measly trickle of the kind of consciousness which will help us to stay alive on the surface of this particular planet.” Mescaline and LSD, he theorized, inhibited the systems in the brain designed to shut out impractical stimulation, so humans could keep coloring within the lines and go about the business of survival without being distracted by the astounding awesomeness of the universe—or as Huxley put it, “the glory, the infinite value and meaningfulness of naked existence, of the given, unconceptualized event.” Huxley

First, when you try to restrict calories and exercise more, your body is hardwired to perceive a starvation situation. That makes you tired (so you move less and conserve energy) and hungry (so you eat more), and it slows down your metabolism (so you don’t die!). This “eat less, exercise more” formula is not too successful for most people. It can work for a short time, certainly, but less than 10 percent of people lose weight and keep it off for a year;4 you will almost always rebound and gain back the weight. Second, when you eat carbs and sugar, insulin spikes and your blood sugar drops. The insulin drives most of the available fuel in your bloodstream into fat cells, especially the fat cells around your middle, otherwise known as belly fat. So your body is starved of fuel, and this stimulates your brain5 to make you eat more.6 You could have a year’s worth of stored energy in your fat tissue and yet feel like you are starving. The only thing that can stop this vicious cycle is eating a lot of fat and cutting out the refined carbs and sugar. A high-fat, low-carb diet leads to a faster metabolism and sustained weight loss.

Another experiment, conducted by Pascual-Leone when he was a researcher at the National Institutes of Health, provides even more remarkable evidence of the way our patterns of thought affect the anatomy of our brains. Pascual-Leone recruited people who had no experience playing a piano, and he taught them how to play a simple melody consisting of a short series of notes. He then split the participants into two groups. He had the members of one group practice the melody on a keyboard for two hours a day over the next five days. he had the members of the other group sit in front of a keyboard for the same amount of time but only imagine playing the song--without ever touching the keys. Using a technique called transcranial magnetic stimulation, or TMS, Pascual-Leone mapped the brain activity of all the participants before, during, and after the test. he found that the people who had only imagined playing the notes exhibited precisely the same changes in their brains as those who had actually pressed the keys. Their brains had changed in response to actions that took place purely in their imaginations--in response, that is, to their thoughts. Descartes may have been wrong about dualism, but he appears to have been correct in believing that our thoughts can exert a physical influence on, or at least cause a physical reaction in, our brains. We become, neurologically, what we think. (p33)

quite opposite to Descartes’s organ metaphor, our global neuronal workspace does not operate in an input-output manner, waiting to be stimulated before producing its outputs. On the contrary, even in full darkness, it ceaselessly broadcasts global patterns of neural activity, causing what William James called the “stream of consciousness”—an uninterrupted flow of loosely connected thoughts, primarily shaped by our current goals and only occasionally seeking information in the senses. René Descartes could not have imagined a machine of this sort, where intentions, thoughts, and plans continually pop up to shape our behavior. The outcome, I argue, is a “free-willing” machine that resolves Descartes’s challenge

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers. “In these experiments,” writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, “loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind.” A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain’s own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat’s neurophysiological capacity to respond to stress. In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex — but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motivation and self-regulation. Given the relative complexity of human emotional interactions, the influence of the infant-parent relationship on human neurochemistry is bound to be even stronger. In the human infant, the growth of dopamine-rich nerve terminals and the development of dopamine receptors is stimulated by chemicals released in the brain during the experience of joy, the ecstatic joy that comes from the perfectly attuned mother-child mutual gaze interaction. Happy interactions between mother and infant generate motivation and arousal by activating cells in the midbrain that release endorphins, thereby inducing in the infant a joyful, exhilarated state. They also trigger the release of dopamine. Both endorphins and dopamine promote the development of new connections in the prefrontal cortex. Dopamine released from the midbrain also triggers the growth of nerve cells and blood vessels in the right prefrontal cortex and promotes the growth of dopamine receptors. A relative scarcity of such receptors and blood supply is thought to be one of the major physiological dimensions of ADD. The letters ADD may equally well stand for Attunement Deficit Disorder.

This cycle puts the Intuitive-Sensitive in a difficult position. In order to avoid a system ‘shut-down’ they need to recover from the stimulation overload, yet they are faced with their biggest fear in another person – anger. They feel emotionally responsible for others and don’t want an argument, yet feel they need to ‘solve’ anger in another person. And if they can’t fix it, they will leave: they can only compromise themselves for so long before a survival mechanism directed towards self-preservation kicks in.

The essence of the adolescent brain changes that are the essence of healthy ways of living throughout the life span spell the word essence itself: ES: Emotional Spark—honoring these important internal sensations that are more intense during adolescence but serve to create meaning and vitality throughout our lives. SE: Social Engagement—the important connections we have with others that support our journeys through life with meaningful, mutually rewarding relationships. N: Novelty—how we seek out and create new experiences that engage us fully, stimulating our senses, emotions, thinking, and bodies in new and challenging ways. CE: Creative Explorations—the conceptual thinking, abstract reasoning, and expanded consciousness that create a gateway to seeing the world through new lenses.

One of the reasons for learning about type is to recognize that we are constantly motivated, simply by the way we’ve established our neural networks, to shape reality along particular functional lines. Another is to recognize the possibilities for growth and change that exist within—and apart from—the framework we have created for ourselves. Even small changes in our usual way of doing things can make big differences in the way our brain is operating. We develop the ability to think in new ways, and this stimulates creative change in all areas of our lives.

A neurosurgeon once told me about operating on the brain of a young man with epilepsy. As is customary in this kind of operation, the patient was wide awake, under only local anesthesia, while the surgeon delicately explored his exposed cortex, makingsure that the parts tentatively to be removed were not absolutely vital by stimulating them electrically and asking the patient what he experienced. Some stimulations provoked visual flashes or hand-raisings, others a sort of buzzing sensation, but one spot produced a delighted response from the patient: "It's 'Outta Get Me' by Guns N' Roses. my favorite heavy metal band!" I asked the neurosurgeon If he had asked the patient to sing or hum along with the music, since it would be fascinating to learn how "high fidelity" the provoked memory was, would it be in exactly the same key and tempo as the record? Such a song (unliken"Silent Night") has one canonical version. so we could simply have superimposed a recording of the patients humming with the standard record and compared the results. Unfortunately, even though a tape recorder had been running during the operation, thesurgeon hadn't asked the patient to sing along. ''Why not?" I asked, and he replied: "I hate rock music!' Later in the conversation the neurosurgeon happened to remark that he was going to have to operate again on the same young man. and I expressed the hope that he would just check to see if he could restimulate the rock music, and this time ask the fellow to sing along. "I can't do it." replied the neurosurgeon. "since I cut out that part." "It was part of the epileptic focus?" I asked. "No,'' the surgeon replied, ''I already told you — I hate rock music.

Peter Müller (1801–1858) had noticed something puzzling. If he shone light in the eye, put pressure on the eye, or electrically stimulated the nerves of the eye, all of these led to similar sensations of vision—that is, a sensation of light rather than of pressure or electricity. This suggested to him that we are not directly aware of the outside world, but instead only of the signals in the nervous system.8 In other words, when the nervous system tells you that something is “out there”—such as a light—that is what you will believe, irrespective of how the signals get there.

Caffeine has a calming effect on the ADHD brain. The theory is that the brain of people who suffer from the disorder has an overabundance of dopamine transporters, or re-uptake inhibitors. They carry away dopamine too fast, creating a shortage of it. In turn, that affects serotonin and norepinephrine. The combined effect is a reduced ability to focus, especially on tasks that the person doesn’t enjoy, a lesser ability to control impulsivity, and it even messes with the awareness of time. Caffeine stimulates dopamine production in the brain, temporarily filling up the gap created by the rapid

the body is equipped with what Cannon named the stress response, also known as the fight-or-flight response, a survival mechanism that gets flipped on when your brain perceives a threat. When this hormonal cascade is triggered by a thought or emotion in the mind, such as fear, the hypothalamic-pituitary-adrenocortical (HPA) axis activates, thereby stimulating the sympathetic nervous system to race into overdrive, pumping up the body’s cortisol and adrenaline levels. Over time, filling the body with these stress hormones can manifest as physical symptoms, predisposing the body to disease over time.

It makes sense. It's all there. Everything that's beautiful or wise or significant has been written down at some time or other. How can anybody have the gall or the self-satisfaction to ignore all that? Who would want to? You read to feel alive, to bring things to life in yourself that you didn't know were there. All those folds and creases in your brain have some function, some potential, all the nerve endings are waiting to be stimulated. And it's all in the books. Everything. The whole fucking world is there if you know how to find it. Reading isn't an escape from life. It is life. It creates life.

Very well. Now, if you stimulate those damaged places in your brain again, you run the risk of opening up the old wounds. I mean, that if you get nerve-sensations of any kind producing the reactions which we call horror, fear, and sense of responsibility, they may go on to make disturbance right along the old channel, and produce in their turn physical changes which you will call by the names you were accustomed to associate with them—dread of German mines, responsibility for the lives of your men, strained attention and the inability to distinguish small sounds through the overpowering noise of guns.”   “I

Lithium regulates the proteins that control the body’s inner clock. This clock runs, oddly, on DNA, inside special neurons deep in the brain. Special proteins attach to people’s DNA each morning, and after a fixed time they degrade and fall off. Sunlight resets the proteins over and over, so they hold on much longer. In fact, the proteins fall off only after darkness falls—at which point the brain should “notice” the bare DNA and stop producing stimulants. This process goes awry in manic-depressives because the proteins, despite the lack of sunlight, remain bound fast to their DNA. Their brains don’t realize they should stop revving.

Bruce has wrestled with his moods, and a psyche genetically prone to extremes, for most of his adult life. Decades of psychotherapy helped reveal and cast light on some of his most primal traumas and conflicts, but his raw moods, and occasional descents into full-blown depression, never quite went away. "You go through periods of being good, then something stimulates it," he says. "The clock, some memory. You never know. The mind wants to link all your feelings to a cause. I'm feeling that because I'm doing this, or because that happened." Eventually Bruce realized that his worst moods had nothing to do with what was actually taking place in his life. Awful, stressful things could happen - conflicts, stress, disappointments, death - and he'd be unflappable. Then things would be peaceful and easy and he'd find himself on his knees. "You're going along fine, and then boom, it hits you. Things that just come from way down in the well. Completely noncasual, but it's part of your DNA, part of the way your body cycles." Bruce knows his particular brain chemistry will never leave him completely in the clear. "You manage it, you learn and evolve, but another recognition you gotta have is that these are the cards you were dealt," he says. "These things are never going to be out of your life. You gotta be constantly vigilant and realistic about these things.

There may be a genetic basis to how much dopamine each of our brains produces. The gene that codes for the production of dopamine is called DRD4 (dopamine receptor D4) and is located on the short arm of the eleventh chromosome. When dopamine is released by certain neurons in the brain it is picked up by other neurons that are receptive to its chemical structure, thereby establishing dopamine pathways that stimulate organisms to become more active and reward certain behaviors that then get repeated. If you knock out dopamine from either a rat or a human, for example, they will become catatonic. If you overstimulate the production of dopamine, you get frenetic behavior in rats and schizophrenic behavior in humans.

Human desire tends to be insatiable. We are so anxious for pleasure that we can never get enough of it. We stimulate our sense organs until they become insensitive, so that if pleasure is to continue they must have stronger and stronger stimulants. In self-defense the body gets ill from the strain, but the brain wants to go on and on. The brain is in pursuit of happiness, and because the brain is much more concerned about the future than the present, it conceives happiness as the guarantee of an indefinitely long future of pleasures. Yet the brain also knows that it does not have an indefinitely long future, so that, to be happy, it must try to crowd all the pleasures of Paradise and eternity into the span of a few years.

Every waking moment, our brains and bodies assimilate a myriad of sensory stimulation from the environment, as well as images, thoughts, emotions, body sensations, and movements from our internal state. In a millisecond, through operations so complex that they elude the full understanding of even the most brilliant minds, our brains compare this wealth of current data to memories of past experience. The most critical purpose of this comparison is to predict the next moment with sufficient accuracy so that we can make an adaptive physical action (Llinas, 2001). What we expect to happen in the very next instant determines the immediate action we make, whether it is reaching out to another person or for an object, such as a cup of tea.

But Nozick did think long and hard about the relationship between hedonism and happiness. He once devised a thought experiment called the Experience Machine. Imagine that “superduper neuropsychologists” have figured out a way to stimulate a person’s brain in order to induce pleasurable experiences. It’s perfectly safe, no chance of a malfunction, and not harmful to your health. You would experience constant pleasure for the rest of your life. Would you do it? Would you plug into the Experience Machine? If not, argued Nozick, then you’ve just proved that there is more to life than pleasure. We want to achieve our happiness and not just experience it. Perhaps we even want to experience unhappiness, or at least leave open the possibility of unhappiness, in order to truly appreciate happiness.

So let’s consider an alternative diet, say 1200 kcal consisting of 30% protein, 15% carbs (i.e., 180 kcal or 45 grams), and 55% fat. After a week or two of getting adapted (during which you may experience some of the fuel limitation symptoms discussed above), your serum ketones rise up in the range (1-2 millimolar) where they meet at least half of the brain’s fuel supply. Now if you go for that 5 mile run, almost all of your body’s muscle fuel comes from fat, leaving your dietary carb intake plus gluconeogenesis from protein to meet the minor fraction of your brain’s energy need not provided from ketones. And, oh yes, after your run while on the low carb diet, your ketone levels actually go up a bit (not dangerously so), further improving fuel flow to your brain. So what does this mean for the rest of us who are not compulsive runners? Well, this illustrates that the keto-adapted state allows your body more flexibility in meeting its critical organ energy needs than a ‘balanced’ but energy-restricted diet. And in particular, this also means that your brain is a “carbohydrate dependent organ” (as claimed by the USDA Dietary Guidelines Advisory Committee as noted in Chapter 3) ONLY when you are eating a high carbohydrate diet. When carbohydrate is restricted as in the example above, your body’s appropriate production of ketones frees the brain from this supposed state of ‘carbohydrate dependency’. And because exercise stimulates ketone production, your brain’s fuel supply is better supported during and after intense exercise when on a low carbohydrate diet than when your carbohydrate intake is high (see below).

In addition to localized neural networks, hallucinogenic drugs have been documented to trigger such preternatural experiences, such as the sense of floating and flying stimulated by atropine and other belladonna alkaloids. These can be found in mandrake and jimsonweed and were used by European witches and American Indian shamans, probably for this very purpose.32 Dissociative anesthetics such as the ketamines are also known to induce out-of-body experiences. Ingestion of methylenedioxyamphetamine (MDA) may bring back long-forgotten memories and produce the feeling of age regression, while dimethyltryptamine (DMT)—also known as “the spirit molecule”—causes the dissociation of the mind from the body and is the hallucinogenic substance in ayahuasca, a drug taken by South American shamans. People who have taken DMT report “I no longer have a body,” and “I am falling,” “flying,” or “lifting up.

You’ve probably also noted the impacts of virtual distraction on your own and others’ behaviors: memory loss, inability to concentrate, being asked to repeat what you just said, miscommunication the norm, getting lost online and wasting time you don’t have, withdrawing from the real world. The list of what’s being lost is a description of our best human capacities—memory, meaning, relating, thinking, learning, caring. There is no denying the damage that’s been done to humans as technology took over—our own Progress Trap. The impact on children’s behavior is of greatest concern for its present and future implications. Dr. Nicolas Kardaras, a highly skilled physician in rehabilitation, is author of Glow Kids: How Screen Addiction Is Hijacking Our Kids—and How to Break the Trance. He describes our children’s behavior in ways that I notice in my younger grandchildren: “We see the aggressive temper tantrums when the devices are taken away and the wandering attention spans when children are not perpetually stimulated by their hyper-arousing devices. Worse, we see children who become bored, apathetic, uninteresting and uninterested when not plugged in.”17 These very disturbing behaviors are not just emotional childish reactions. Our children are behaving as addicts deprived of their drug. Brain imaging studies show that technology stimulates brains just like cocaine does.

Subject: SELF WORTH (Very Deep!!!) In a brief conversation, a man asked a woman he was pursuing the question: 'What kind of man are you looking for?' She sat quietly for a moment before looking him in the eye & asking, 'Do you really want to know?' Reluctantly, he said, 'Yes. She began to expound, 'As a woman in this day & age, I am in a position to ask a man what can you do for me that I can't do for myself? I pay my own bills. I take care of my household without the help of any man... or woman for that matter. I am in the position to ask, 'What can you bring to the table?' The man looked at her. Clearly he thought that she was referring to money. She quickly corrected his thought & stated, 'I am not referring to money. I need something more. I need a man who is striving for excellence in every aspect of life. He sat back in his chair, folded his arms, & asked her to explain. She said, 'I need someone who is striving for excellence mentally because I need conversation & mental stimulation. I don't need a simple-minded man. I need someone who is striving for excellence spiritually because I don't need to be unequally yoked...believers mixed with unbelievers is a recipe for disaster. I need a man who is striving for excellence financially because I don't need a financial burden. I need someone who is sensitive enough to understand what I go through as a woman, but strong enough to keep me grounded. I need someone who has integrity in dealing with relationships. Lies and game-playing are not my idea of a strong man. I need a man who is family-oriented. One who can be the leader, priest and provider to the lives entrusted to him by God. I need someone whom I can respect. In order to be submissive, I must respect him. I cannot be submissive to a man who isn't taking care of his business. I have no problem being submissive...he just has to be worthy. And by the way, I am not looking for him...He will find me. He will recognize himself in me. Hey may not be able to explain the connection, but he will always be drawn to me. God made woman to be a help-mate for man. I can't help a man if he can't help himself. When she finished her spill, she looked at him. He sat there with a puzzled look on his face. He said, 'You are asking a lot. She replied, "I'm worth a lot". Send this to every woman who's worth a lot.... and every man who has the brains to understand!!

ASPARTAME AND MSG: EXCITOTOXINS Aspartame is, in fact, an excitotoxin, one of a group of substances, usually acidic amino acids, that in high amounts react with specialized receptors in the brain, causing destruction of certain types of neurons. A growing number of neurosurgeons and neurologists are convinced that excitotoxins play a critical role in the development of several neurological disorders, including migraines, seizures, learning disorders in children, and neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS).1 Glutamate and aspartate are two powerful amino acids that act as neurotransmitters in the brain in very small concentrations, but they are also commonly available in food additives. Glutamate is in MSG, a flavor enhancer, and in hydrolyzed vegetable protein, found in hundreds of processed foods. Aspartate is one of three components of aspartame (NutraSweet, Equal), a sugar substitute. In higher concentrations as food additives, these chemicals constantly stimulate brain cells and can cause them to undergo a process of cell death known as excitotoxicity—the cells are excited to death.

After all, across the population there are slight differences in brain function, and sometimes these translate directly into different ways of experiencing the world. And each individual believes his way is reality. To get a sense of this, imagine a world of magenta Tuesdays, tastes that have shapes, and wavy green symphonies. One in a hundred otherwise normal people experience the world this way, because of a condition called synesthesia (meaning “joined sensation”).5 In synesthetes, stimulation of a sense triggers an anomalous sensory experience: one may hear colors, taste shapes, or systematically experience other sensory blendings. For example, a voice or music may not only be heard but also seen, tasted, or felt as a touch. Synesthesia is a fusion of different sensory perceptions: the feel of sandpaper might evoke an F-sharp, the taste of chicken might be accompanied by a feeling of pinpoints on the fingertips, or a symphony might be experienced in blues and golds. Synesthetes are so accustomed to the effects that they are surprised to find that others do not share their experiences. These synesthetic experiences are not abnormal in any pathological sense; they are simply unusual in a statistical sense.

Walking into a bookshop is a depressing thing. It’s not the pretentious twats, browsing books as part of their desirable lifestyle. It’s not the scrubby members of staff serving at the counter: the pseudo-hippies and fucking misfits. It’s not the stink of coffee wafting out from somewhere in the building, a concession to the cult of the coffee bean. No, it’s the books. I could ignore the other shit, decide that maybe it didn’t matter too much, that when consumerism meets culture, the result is always going to attract wankers and everything that goes with them. But the books, no, they’re what make your stomach sink and that feeling of dark syrup on the brain descend. Look around you, look at the shelves upon shelves of books – for years, the vessels of all knowledge. We’re part of the new world now, but books persist. Cheap biographies, pulp fiction; glossy covers hiding inadequate sentiments. Walk in and you’re surrounded by this shit – to every side a reminder that we don’t want stimulation anymore, we want sedation. Fight your way through the celebrity memoirs, pornographic cook books, and cheap thrills that satisfy most and you get to the second wave of vomit-inducing product: offerings for the inspired and arty. Matte poetry books, classics, the finest culture can provide packaged and wedged into trendy coverings, kidding you that you’re buying a fashion accessory, not a book. But hey, if you can stomach a trip further into the shop, you hit on the meatier stuff – history, science, economics – provided they can stick ‘pop.’ in front of it, they’ll stock it. Pop. psychology, pop. art, pop. life. It’s the new world – we don’t want serious anymore, we want nuggets of almost-useful information. Books are the past, they’re on the out. Information is digital now; bookshops, they’re somewhere between gallery and museum.

Original Statement by Hunger Strikers to Psychiatric Association, National Alliance for the Mentally Ill and the U.S. Office of the Surgeon General 1. A Hunger Strike to Challenge International Domination by Biopsychiatry. This fast is about human rights in mental health. The psychiatric pharmaceutical complex is heedless of its oath to “first do no harm.” Psychiatrists are able with impunity to: Incarcerate citizens who have committed crimes against neither persons nor property. Impose diagnostic labels on people that stigmatize and defame them. Induce proven neurological damage by force and coercion with powerful psychotropic drugs. Stimulate violence and suicide with drugs promoted as able to control these activities. Destroy brain cells and memories with an increasing use of electroshock (also known as electro-convulsive therapy). Employ restraint and solitary confinement—which frequently cause severe emotional trauma, humiliation, physical harm, and even death—in preference to patience and understanding. Humiliate individuals already damaged by traumatizing assaults to their self-esteem. These human rights violations and crimes against human decency must end. While the history of psychiatry offers little hope that change will arrive quickly, initial steps can and must be taken. At the very least, the public has the right to know IMMEDIATELY the evidence upon which psychiatry bases its spurious claims and treatments, and upon which it has gained and betrayed the trust and confidence of the courts, the media, and the public.21

The firm’s fourth partner, Jeff Nussbaum, had carved out a niche writing jokes for public figures. It was he who taught me about the delicate balance all public-sector humorists hope to strike. Writing something funny for a politician, I learned, is like designing something stunning for Marlon Brando past his prime. The qualifier is everything. At first I didn’t understand this. In June, President Obama’s speechwriters asked Jeff to pitch jokes for an upcoming appearance at the Radio and Television Correspondents’ Dinner. I sent him a few ideas, including one about the president and First Lady’s recent trip to see a Broadway show: “My critics are upset it cost taxpayer dollars to fly me and Michelle to New York for date night. But let me be clear. That wasn’t spending. It was stimulus.” Unsurprisingly, my line about stimulating America’s first couple didn’t make it into the script. But others did. The morning after the speech, I watched on YouTube as President Obama turned to NBC reporter Chuck Todd. “Chuck embodies the best of both worlds: he has the rapid-fire style of a television correspondent, and the facial hair of a radio correspondent.” That was my joke! I grabbed the scroll bar and watched again. The line wasn’t genius. The applause was largely polite. Still, I was dumbfounded. A thought entered my brain, and then, just a few days later, exited the mouth of the president of the United States. This was magic. Still, even then, I had no illusions of becoming a presidential speechwriter. When friends asked if I hoped to work in the White House, I told them Obama had more than enough writers already. I meant it.