Brain Donors Quotes

On April 2, the nurses started my first round of five intravenous immunoglobulin (IVIG) infusions. The clear IV bags hung on a metal pole above my head, their liquid trickling down into my vein. Each of those ordinary-looking bags contained the healthy antibodies of over a thousand blood donors and cost upwards of $20,000 per infusion. One thousand tourniquets, one thousand nurses, one thousand veins, one thousand blood-sugar regulating cookies, all just to help one patient.

Journalists sometimes speculate about “brain transplants” when they really should be calling them “body transplants,” because, as the philosopher Dan Dennett has noted, this is the one transplant operation in which it is better to be the donor than the recipient.

If there were ever a cadaver eligible for sainthood, it would not be our Spalding Gray upon the cross, it would be these guys: the brain-dead, beating-heart organ donors that come and go in our hospitals every day.

Singin' In the Rain might get you through an anxious week or two, but it won't get you through an anxious life. For that you need either a brain transplant (the only procedure of its kind, it has been said, in which it is better to be a donor than a recipient), a fully stocked bomb shelter, or a thorough adjustment of your perspective on existential risk and reward.

When we notice someone suffering and immediately decide to help them, it “says” to our associates, “See how easily I’m moved to help others? When people near me are suffering, I can’t help wanting to make their situation better; it’s just who I am.” This is a profoundly useful trait to advertise; it means you’ll make a great ally. The more time other people spend around you, the more they’ll get to partake of your spontaneous good will. It’s this function of charity that accounts for a lot of the puzzles we discussed earlier. For one, it explains why we donate so opportunistically. Most donors don’t sketch out a giving strategy and follow through as though it were a business plan.

Scientists have identified individual neurons, which fire, when a particular person has been recognized. Thus, [it is possible that] when a recipient’s brain analyzes the features of a person, who significantly impressed the donor, the donated organ may feed back powerful emotional messages, which signal recognition of the individual. Such feedback messages occur within milliseconds and the recipient [may even believe] that [he] knows the person.” —“Cellular Memory in Organ Transplants

I understand that it’s disheartening to pour effort and money into a work of art and find that others do not value it with the same intensity. I’ve been to this rodeo more than a few times, and yes, it’s painful and hard on the soul. It is also the sort of thing that grown-ups do every day. Anyone deluded enough to think they are owed monetary success because they bled for their art is in for some hard, hard knocks and buckets full of tears. There will be many cries of “unfair” and much jealousy and hatred. And to be fair, all authors go through this every time they watch their books ride the waves of bestseller charts and the ego torture chamber known as Goodreads reviews. Even the most well-adjusted of us watch that horrible piece of shit book beat our baby to pieces and gnash our teeth and shout at our monitors demanding to know what brain-donors are shopping on amazon.com these days. But holy Smart Bitch on a cracker, Batman, to write a post about how stupid readers are and worse to actually put it out there on the internet is so beyond the pale there’s a special hell for that kind of idiocy. Let me repeat: authors exist at the pleasure of readers. Without the people who buy and read my books, I am just another dizzy broad writing shit down. Readers aren’t just an author’s audience; they are her lifeblood. --

With that Nox turned a knob. There was a delay, but that was how the machine worked. First it gathered information about the subject, feeling, sensing—like a fighter in a ring, circling his opponent. Kaleb sensed it, too. It was as if a doctor palpated his flesh, pushing his skin. It tingled gently. The tingling surged through his whole body. Was this it? Kaleb thought. Visions from his past shot through his brain. His mother. Father. Zenobia. Joan and Reck. The Three Musketeers. Pleasant memories. Then the machine found what it searched for, and it acted. Waves of pain shot through his entire body, causing him to arch his back. He screamed in agony, his screams reverberating across the canyon. Then all of his muscles constricted. He couldn’t breathe, couldn’t even scream. It seemed to last forever. It stopped, and his muscles relaxed, allowing him to breath.

My brain remembers Jesse’s best friend, Zara. The mother of Jesse’s first daughter, Zara. Our egg donor, Zara. Our surrogate, Zara.

Similar things happen in so many diseases – the insulin-secreting cells that are lost when teenagers develop type 1 diabetes, the brain cells that are lost in Alzheimer’s disease, the cartilage producing cells that disappear during osteoarthritis – the list goes on and on. It would be great if we could replace these with new cells, identical to our own. This way we wouldn’t have to deal with all the rejection issues that make organ transplants such a challenge, or with the lack of availability of donors. Using stem cells in this way is referred to as therapeutic cloning; creating cells identical to a specific individual in order to treat a disease.

Sperm cells turned out to be surprisingly canny in that they seemed to be capable of identifying and reacting to the presence of their own donor, ignoring the presence of other males. Such observations seem to imply that some sort of total memory may go down to the single cell, and by inference that the brain may be just a switching mechanism, not necessarily a memory storage organ.

He subscribed to the medieval policy of polypharmacy – chucking in sometimes dozens of ingredients on the principle that some of them were bound to do you good, ignoring the possibility that some of them might be toxic. As well as ‘fistfuls’ and ‘half-handfuls’ of miscellaneous greenery, ivory shavings cropped up quite often, sometimes having been burned first. The genitals of a cockerel might come in useful, if you could find them. Breast milk should be drunk ‘from the breast by sucking, and if this be loathsome to the patient [regardless of the feelings of the donor] let him take it as hot as possible’. Cat lovers would be horrified by Gaddesden’s recommendation of an ‘astringent bath: take young cats, cut their entrails out, and put their extremities [paws and tail?] with [various herbs], boil in water and bathe the sick man in it’. Another feline recipe: put ‘the lard’ of a black cat, and of a dog, into the belly of a previously eviscerated and flayed black cat, and roast it; collect the ‘juice’ and rub it on the sick limb. ‘The comfort derived therefrom is marvellous.’ A specific for nervous disease is the brain of a hare. If the hunting party kills a fox instead, they could boil it up and use the resulting broth for a massage. Treatment for a paralysed tongue sounds more cheerful: rub it with what the translator called ‘usquebaugh’, i.e. whisky; ‘it restores the speech, as has been proved on many people’. Animal and avian droppings found many uses, such as peacocks’ droppings for a boil. A cowpat made a good poultice, with added herbs. For those who could afford them, gold and silver and pearls, both bored and unbored, were bound to increase the efficacy of the medicine. Gaddesden recommended his own electuary, using eighteen ingredients including burnt ivory and unbored pearls, with a pound of (very expensive) sugar; ‘I have often proved its goodness myself.’ In a final flourish, he suggests putting the heart of a robin redbreast round the neck of a ‘lethargic’ patient, to keep him awake, or hanging the same heart, with an owl’s heart, above an amnesiac patient; it will ‘give [his memory] back to him’. Even better, the heart of a swallow cooked in honey ‘compels him who eats it to tell all things that happened’ in the past, and to predict the future.

She spoke wearily, her eyes rimmed a permanent shade of red. “They say we need to take him off of life support. That his body is deteriorating.” The wail of Brandon’s mom came down the hallway. It had become a sound we knew all too well. She broke down at random. Everyone did. Well, everyone except for me. I was void of emotion while my predator and I shared space. Instead of feeling pain at Sloan’s suffering, I spiraled further into my OCD. I slept less. I moved more. I dove deeper into my rituals. And nothing helped. Sloan didn’t react to the sound of grief down the hall. “His brain isn’t making hormones anymore or controlling any of his bodily functions. The medications he’s on to maintain his blood pressure and body temperature are damaging his organs. They said if we want to donate them, we have to do it soon.” “Okay,” I said, pulling tissues from a box and shoving them into her hands. “When are they doing it?” She spoke to the room, to someplace behind me. She didn’t look at me. “They’re not.” I stared at her. “What do you mean they’re not?” She blinked, her eyelids closing mechanically. “His parents don’t want to take him off life support. They’re praying for a miracle. They’re really religious. They think he rebounded once and he’ll rebound again.” Her eyes focused on me, tears welled, threatening to fall. “It’s going to all be for nothing, Kristen. He’s an organ donor. He’d want that. He’s going to rot in that room and he’s going to die for nothing and I have no say in any of it.” The tears spilled down her face, but she didn’t sob. They just streamed, like water from a leaky hose. I gaped at her. “But…but why? Didn’t he have a will? What the fuck?” She shook her head. “We talked about it, but the wedding was so close we just decided to wait. I have no say. At all.” The reality suddenly rolled out before me. It wouldn’t just be this. It would be everything. His life insurance policy, his benefits, his portion of the house, his belongings—not hers. She would get nothing. Not even a vote. She went on in her daze. “I don’t know how to convince them. The insurance won’t cover his stay much longer, so they’ll be forced to make a decision at some point. But it will cover it long enough for his organs to fail.” My brain grasped at a solution. “Claudia. She might be able to convince them.” She hadn’t been able to make the meeting. And she would side with Sloan—I knew she would. She had influence on her parents. “Maybe Josh too,” I continued. “They like him. They might listen to him.” I stood. She looked up at me, a tear dripping off her chin and landing on her thigh. “Where are you going?” “To find Josh.

Findings have become common on brain-like processes outside of the skull. The conductive structure inside the heart, like pacemaker cells, which organizes the heartbeat, can be known as the brain of the heart, just as the intestine's brain is the ganglion cells in the gut. Conduction system independence is shown when a transplanted heart continues to beat even though the nerves that connected it to the central and peripheral nervous systems of the donor have been severed. The interaction between the independent processing of the heart and that of the brain is complex and not fully understood. The trillions of bacteria that outnumber the cells of the body by ten to one are even more enigmatic, residing mostly within the digestive tract but also on the skin and in the brain and other organs. We think of these bacteria as pests, but these micro-organisms were simply introduced in vast stretches along the double helix of human DNA over eons. The consequences are immense and essentially uncharted for what we call "being alive" The bacterial part of the body, taken as a whole, is called the microbiome. It is not sitting on the skin or in the gut passively, nor is it invading the body. Actually, the microbiota is the barrier between "in here" and "out there," containing DNA, antibodies, and chemical signaling that allows the brain to do the same stuff. There is no clear role of the microbial DNA that is incorporated into our genomes, but at least this is ancestral material that we have assimilated as our own. More suggestively, this once-foreign DNA in all higher life-forms may be the swapping mechanism for genes. These discoveries demonstrate that our intelligence extends to the whole of ecology. Everywhere mentality has a physical basis. Any attempt at isolating it in the skull comes up against serious objections. Instead of treating cynicism with unbounded consciousness, we need to see that every perception is unbounded. By going beyond the illusory boundaries of the disconnected body, you cannot see, hear or touch anything in the universe. Watching a sunset is like watching yourself, actually.