Aubrey De Grey Quotes

Your future self is watching you right now through your memories.

Don’t cling to a mistake just because you spent a lot of time making it.

I think it's reasonable to suppose that one could oscillate between being biologically 20 and biologically 25 indefinitely.

I have been aware for many years that most people do not think about aging in the same way that they think about cancer, or diabetes, or heart disease. They are strongly in favor of the absolute elimination of such diseases as soon as possible, but the idea of eliminating aging—maintaining truly youthful physical and mental function indefinitely—evokes an avalanche of fears and reservations. Yet, in the sense that matters most, aging is just like smoking: It’s really bad for you.

You do can something, right? We are at the time where we do not have to pretend that there’s nothing that can be done. There are things that can be done, and as Silicon Valley tech billionaire Peter Thiel said, they’re underfunded. No one cares about them. Poor Aubrey de Grey has been giving talks on TED and at Google, and no one believes. The listeners are just thinking, “Eh, crazy guy. Death is cool.

The fact that all the diseases of old age have a progression that is exponentially related to age. In other words your chance of having Alzheimer’s, for example, at age seventy-five is twice that at age seventy. And your chance of having it age eighty is twice what it was at age seventy-five.

That is actually a real kicker when it comes longevity, because it means even if we completely eliminated atherosclerosis from the population it would still only extend people’s healthy lifespan and therefore people’s total lifespan by three or four years.

Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing. For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability." "David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale. When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives." "I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000 So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first. This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely. Will it happen? At this point, there is no doubt that it will happen eventually. It's not a question of if but when.

P4 - The good news is that there is at least one emerging technology out there that is looking mighty promising right now: it’s called helium persufflation, and I’m currently orchestrating the funding of the most critical research into making it work. Over the course of 2023 LEV Foundation has coordinated an effort, conceived by Martin O’Dea and Dr. Aubrey de Grey, to lay to rest the lamentable opinion that aging, along with the disease and death it brings, is inevitable - and by extension, that attempts to combat it are unworthy of serious recognition or support. We assert instead that an immediate expansion of work to extend healthy lifespans is not only credible, but indeed crucial to the quality of our collective future. In collaboration with primary author Professor Brian Kennedy, with input and enthusiastic endorsement from iconic researchers and leaders across the field of longevity medicine and allied fields, we are now able to publish the result of that effort - the Dublin Longevity Declaration: Consensus Recommendation to Immediately Expand Research on Extending Healthy Human Lifespans. Whatever your background, we encourage everyone who reads the Declaration and agrees with its message to add your signature, and encourage your friends and colleagues to consider doing the same: www. dublinlongevitydeclaration. org More on all of this here: www. quora. com/profile/Aubrey-de-Grey/answers

This is longevity escape velocity.[100] This is why there is sound logic behind Aubrey de Grey’s sensational declaration that the first person to live to 1,000 years has likely already been born.

The first, originally published in 2002 and boldly entitled “Strategies for Engineered Negligible Senescence” (SENS for short), was devised by maverick biogerontologist Aubrey de Grey. In its current form, SENS identifies seven differences between old bodies and young which de Grey suggests are the fundamental causes of aging.

You can live long enough to live forever.” —Ray Kurzweil, Inventor and Futurist “The first person to live to 150 has already been born.” —Dr. Aubrey de Grey, Biogerontologist “Until death, it is all life.” —Miguel de Cervantes, Author, Don Quixote

P1 - Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing. For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability." "David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale. When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives." "I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000 So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first. This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely. Will it happen? At this point, there is no doubt that it will happen eventually. It's not a question of if but when.

Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing. For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability." "David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale. When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives." "I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000 So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first. This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely. Will it happen? At this point, there is no doubt that it will happen eventually.

P3 - ten minutes of that movie, or indeed of any movie whose message is similarly dystopian about a post-aging world (Blade Runner), you will see that they set it up by insinuating, with exactly no justification and also no attempt at discussion (which is how they get away with not justifying it), that the defeat of aging will self-evidently bring about some new problem that we will be unable to solve without doing more harm than good. The most common such problem, of course, is overpopulation - and I refer you to literally about 1000 interviews and hundreds of talks I have given on stage and camera over the past 20 years, of which several dozen are online, for why such a concern is misplaced. The reason there are 1000, of course, is that most people WANT to believe that aging is a blessing in disguise - they find it expedient to put aging out of their minds and get on with their miserably short lives, however irrational must be the rationalizations by which they achieve that. Aubrey has been asked on numerous occasions whether humans should use future tech to extend their lifespans. Aubrey opines, "I believe that humans should (and will) use (and, as a prerequisite, develop) future technologies to extend their healthspan, i.e. their healthy lifespan. But before fearing that I have lost my mind, let me stress that that is no more nor less than I have always believed. The reason people call me an “immortalist” and such like is only that I recognize, and am not scared to say, two other things: one, that extended lifespan is a totally certain side-effect of extended healthspan, and two, that the desire (and the legitimacy of the desire) to further extend healthspan will not suddenly cease once we achieve such-and-such a number of years." On what people can do to advance longevity research, my answer to this question has radically changed in the past year. For the previous 20 years, my answer would have been “make a lot of money and give it to the best research”, as it was indisputable that the most important research could go at least 2 or 3x times faster if not funding-limited. But in the past year, with the influx of at least a few $B, much of it non-profit (and much of it coming from tech types who did exactly the above), the calculus has changed: the rate-limiter now is personnel. It’s more or less the case now that money is no longer the main rate-limiter, talent is: we desperately need more young scientists to see longevity as the best career choice. As for how much current cryopreservation technology will advance in the next 10-20 years, and whether it enough for future reanimation? No question about the timeframe for a given amount of progress in any pioneering tech can be answered other than probabilistically. Or, to put it more simply, I don’t know - but I think there's a very good chance that within five years we will have cryo technology that inflicts only very little damage on biological tissue, such that yes, other advances in rejuvenation medicine that will repair the damage that caused the cryonaut to be pronounced dead in the first place will not be overwhelmed by cryopreservation damage, hence reanimation will indeed be possible. As of now, the people who have been cryopreserved(frozen) the best (i.e. w/ vitrification, starting very shortly immediately after cardiac arrest) may, just possibly, be capable of revival by rewarming and repair of damage - but only just possibly. Thus, the priority needs to be to improve the quality of cryopreservation - in terms of the reliability of getting people the best preservation that is technologically possible, which means all manner of things like getting hospitals more comfortable with cryonics practice and getting people to wear alarms that will alert people if they undergo cardiac arrest when alone, but even more importantly in terms of the tech itself, to reduce (greatly) the damage that is done to cells and tissues by the cryopreservation process.

P2 - We are well on the way in a number of areas. Both billionaires and big Pharma are getting increasingly interested and money is starting to pour into research because it is clear we can see the light at the end of the tunnel which to investors equates to return on investment. Numerous factors will drive things forward and interest and awareness is increasing rapidly among both scientists, researchers and the general population as well as wealthy philanthropists. The greatest driving force of all is that the baby boomers are aging and this will place increasing demands on healthcare systems. Keep in mind that the average person costs more in medical expenditure in the last year of their life than all the other years put together. Also, the number of workers is declining in most developed countries which means that we need to keep the existing population working and productive as long as possible. Below are a list which are basically all technologies potentially leading to radical life extension with number 5 highlighted which I assume might well be possible in the second half of the century: 1. Biotechnology - e.g stem cell therapies, enhanced autophagy, pharmaceuticals, immunotherapies, etc 2. Nanotechnology - Methods of repairing the body at a cellular and molecular level such as nanobots. 3. Robotics - This could lead to the replacement of increasing numbers of body parts and tends to go hand in hand with AI and whole brain emulation. It can be argued that this is not life extension and that it is a path toward becoming a Cyborg but I don’t share that view because even today we don’t view a quadriplegic as less human if he has four bionic limbs and this will hold true as our technology progresses. 4. Gene Therapies - These could be classified under the first category but I prefer to look at it separately as it could impact the function of the body in very dramatic ways which would suppress genes that negatively impact us and enhance genes which increase our tendency toward longer and healthier lives. 5. Whole brain emulation and mindscaping - This is in effect mind transfer to a non biological host although it could equally apply to uploading the brain to a new biological brain created via tissue engineering this has the drawback that if the original brain continues to exist the second brain would have a separate existence in other words whilst you are identical at the time of upload increasing divergence over time will be inevitable but it means the consciousness could never die provided it is appropriately backed up. So what is the chance of success with any of these? My answer is that in order for us to fail to achieve radical life extension by the middle of the century requires that all of the above technologies must also fail to progress which simply won't happen and considering the current rate of development which is accelerating exponentially and then factoring in that only one or two of the above are needed to achieve life extension (although the end results would differ greatly) frankly I can’t see how we can fail to make enough progress within 10-20 years to add at least 20 to 30 years to current life expectancy from which point progress will rapidly accelerate due to increased funding turning aging at the very least into a manageable albeit a chronic incurable condition until the turn of the 22nd century. We must also factor in that there is also a possibility that we could find a faster route if a few more technologies like CRISPR were to be developed. Were that to happen things could move forward very rapidly. In the short term I'm confident that we will achieve significant positive results within a year or two in research on mice and that the knowledge acquired will then be transferred to humans within around a decade. According to ADG, a dystopian version of the post-aging world like in the film 'In Time' not plausible in the real world: "If you CAREFULLY watch just the first

P4 - The good news is that there is at least one emerging technology out there that is looking mighty promising right now: it’s called helium persufflation, and I’m currently orchestrating the funding of the most critical research into making it work. Over the course of 2023 LEV Foundation has coordinated an effort, conceived by Martin O’Dea and Dr. Aubrey de Grey, to lay to rest the lamentable opinion that aging, along with the disease and death it brings, is inevitable - and by extension, that attempts to combat it are unworthy of serious recognition or support. We assert instead that an immediate expansion of work to extend healthy lifespans is not only credible, but indeed crucial to the quality of our collective future. In collaboration with primary author Professor Brian Kennedy, with input and enthusiastic endorsement from iconic researchers and leaders across the field of longevity medicine and allied fields, we are now able to publish the result of that effort - the Dublin Longevity Declaration: Consensus Recommendation to Immediately Expand Research on Extending Healthy Human Lifespans. Whatever your background, we encourage everyone who reads the Declaration and agrees with its message to add your signature, and encourage your friends and colleagues to consider doing the same: www. dublinlongevitydeclaration. org More on all of this here: www. quora. com/profile/Aubrey-de-Grey/answers