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to measure success or failure. One criticism has been that PSA increases are not always consecutive. A man’s rise in PSA with one test might be followed by a transient decrease in the next, followed by another increase. Although there may be recurrent cancer, under the ASTRO definition, this man’s treatment would still be considered a success—even though it’s just a technicality. “Fortunately, any astute radiation oncologist will not blindly follow the consensus definition in making treatment decisions,” comments Danny Song. A quirk of the ASTRO definition is that, over a short period of time after treatment, it really can’t tell us much. This is due to the gradual nature of radiation’s effects; cancer
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Patrick C. Walsh (Dr. Patrick Walsh's Guide to Surviving Prostate Cancer)