Age Decrease Quotes

We are looking at a society increasingly dependent on machines, yet decreasingly capable of making or even using them effectively.

There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker.

It is one of the unexpected disasters of the modern age that our new unparalleled access to information has come at the price of our capacity to concentrate on anything much. The deep, immersive thinking which produced many of civilization's most important achievements has come under unprecedented assault. We are almost never far from a machine that guarantees us a mesmerizing and libidinous escape from reality. The feelings and thoughts which we have omitted to experience while looking at our screens are left to find their revenge in involuntary twitches and our ever-decreasing ability to fall asleep when we should.

Study, along the lines which the theologies have mapped, will never lead us to discovery of the fundamental facts of our existence. That goal must be attained by means of exact science and can only be achieved by such means. The fact that man, for ages, has superstitiously believed in what he calls a God does not prove at all that his theory has been right. There have been many gods – all makeshifts, born of inability to fathom the deep fundamental truth. There must be something at the bottom of existence, and man, in ignorance, being unable to discover what it is through reason, because his reason has been so imperfect, undeveloped, has used, instead, imagination, and created figments, of one kind or another, which, according to the country he was born in, the suggestions of his environment, satisfied him for the time being. Not one of all the gods of all the various theologies has ever really been proved. We accept no ordinary scientific fact without the final proof; why should we, then, be satisfied in this most mighty of all matters, with a mere theory? Destruction of false theories will not decrease the sum of human happiness in future, any more than it has in the past... The days of miracles have passed. I do not believe, of course, that there was ever any day of actual miracles. I cannot understand that there were ever any miracles at all. My guide must be my reason, and at thought of miracles my reason is rebellious. Personally, I do not believe that Christ laid claim to doing miracles, or asserted that he had miraculous power... Our intelligence is the aggregate intelligence of the cells which make us up. There is no soul, distinct from mind, and what we speak of as the mind is just the aggregate intelligence of cells. It is fallacious to declare that we have souls apart from animal intelligence, apart from brains. It is the brain that keeps us going. There is nothing beyond that. Life goes on endlessly, but no more in human beings than in other animals, or, for that matter, than in vegetables. Life, collectively, must be immortal, human beings, individually, cannot be, as I see it, for they are not the individuals – they are mere aggregates of cells. There is no supernatural. We are continually learning new things. There are powers within us which have not yet been developed and they will develop. We shall learn things of ourselves, which will be full of wonders, but none of them will be beyond the natural. [Columbian Magazine interview]

If you want to make money at some point, remember this, because this is one of the reasons startups win. Big companies want to decrease the standard deviation of design outcomes because they want to avoid disasters. But when you damp oscillations, you lose the high points as well as the low. This is not a problem for big companies, because they don't win by making great products. Big companies win by sucking less than other big companies.

With prolonged and repeated exposure to pleasurable stimuli, our capacity to tolerate pain decreases, and our threshold for experiencing pleasure increases.

There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.

We in our age are faced with a strange paradox. Never before have we had so much information in bits and pieces flooded upon us by radio and television and satellite, yet never before have we had so little inner certainty about our own being. The more objective truth increases, the more our inner certitude decreases. Our fantastically increased technical power, and each forward step in technology is experienced by many as a new push toward our possible annihilation. Nietzsche was strangely prophetic when he said, “We live in a period of atomic chaos…the terrible apparition…the Nation State…and the hunt for happiness will never be greater than when it must be caught between today and tomorrow; because the day after tomorrow all hunting time may have come to an end altogether.” Sensing this, and despairing of ever finding meaning in life, people these days seize on the many ways of dulling their awareness by apathy, by psychic numbing, or by hedonism. Others, especially young people, elect in alarming and increasing numbers to escape their own being by suicide.

In all, 86 per cent of the increased life expectancy was due to decreases in infectious diseases. And the bulk of the decline in infectious disease deaths occurred prior to the age of antibiotics. Less than 4 per cent of the total improvement in life expectancy since 1700s can be credited to twentieth-century advances in medical care.

As we age and plasticity declines, it becomes increasingly difficult for us to change in response to the world, even if we want to. We find familiar types of stimulation pleasurable; we seek out like-minded individuals to associate with, and research shows we tend to ignore or forget, or attempt to discredit, information that does not match our beliefs, or perception of the world, because it is very distressing and difficult to think and perceive in unfamiliar ways. Increasingly the aging individual acts to preserve the structures within, and when there is a mismatch between his internal neurocognitive structures and the world, he seek to change the world. In small ways he begins to micromanage his environment, to control it, and make it familiar. But this process, writ large, often leads whole cultural groups to try to impose their view of the world on other cultures, and they often become violent, especially in the modern world, where globalization has brought different cultures closer together, exacerbating the problem. Wexler's point, then, is that much of the cross-cultural conflict we see is a product of the relative decrease in plasticity. One could add that totalitarian regimes seem to have an intuitive awareness that it becomes hard for people to change after a certain age, which is why so much effort is made to indoctrinate the young from an early age.

Are we more likely to suffer from arthritis, stiff joints, poor memory, flagging energy, and decreased sex drive as we age, simply because that’s the version of the truth that ads, commercials, television shows, and media reports bombard us with? What other self-fulfilling prophecies are we creating in our minds without being aware of what we’re doing? And what “inevitable truths” can we successfully reverse simply through thinking new thoughts and choosing new beliefs? The

I choke on my coffee. “I thought libidos decrease with age.”  “I’ve got memories to last me a lifetime.”  Mom groans. “By all means, feel free to take them to your grave.

Secondly, women’s sexual value decreases as they age, meaning there is no guarantee that your beautiful, vivacious, 27 year old bride will remain so at 37.

Secondly, women’s sexual value decreases as they age, meaning there is no guarantee that your beautiful, vivacious, 27 year old bride will remain so at 37. In fact the odds are she wont.

a hallmark of a living system is that it maintains or reduces its entropy by increasing the entropy around it. In other words, the second law of thermodynamics has a life loophole: although the total entropy must increase, it’s allowed to decrease in some places as long as it increases even more elsewhere. So life maintains or increases its complexity by making its environment messier.

But certainly for the present age, which prefers the sign to the thing signified, the copy to the original, representation to reality, the appearance to the essence... illusion only is sacred, truth profane. Nay, sacredness is held to be enhanced in proportion as truth decreases and illusion increases, so that the highest degree of illusion comes to be the highest degree of sacredness.

An Australian study of more than 12,000 adults estimated that every single hour spent watching television after the age of 25 decreased the viewer’s life expectancy by 22 minutes.

But even if such a prediction were true, our inability to distinguish between a virtual reality simulation and the real world will have less to do with the increasing fidelity of simulation than the decreasing perceptual abilities of us humans.

write these pages, Japan and the U.S. are still practicing widespread selective denial of major problems. Japan currently acknowledges some problems (its large government debt and aging population), and incompletely acknowledges the issue of Japanese women’s role. But Japan still denies other problems: its lack of accepted alternatives to immigration for solving its demographic difficulties; the historical causes of Japan’s tense relations with China and Korea; and denial that Japan’s traditional policy of seeking to grab overseas natural resources rather than to help manage them sustainably is now outdated. The U.S., as I write, is still in widespread denial of our own major problems: political polarization, low voter turnout, obstacles to voter registration, inequality, limited socio-economic mobility, and decreasing government investment in public goods.

The hormonal rewards of constantly checking our phones fatigue the mind just as much as the stressors do. Studies of phone addiction have found the little hits of dopamine that keep users jonesing for notifications come with a tragic side effect. They actually inhibit the amount of dopamine we feel when exposed to real-life novelty. Said another way, phone addiction decreases our ability to enjoy new experiences in the physical world. When you’re hooked on novelty in electronic form, new foods and flowers lose their magic.

Several analyses of the University of Michigan Health and Retirement Study have observed a link between a high sense of purpose and decreased mortality in adults over fifty.

I guess everyone gets more attractive as your eyesight decreases with age. That's something to look forward to until you can't see anymore.

I’m not just pretty anymore, I am pretty for my age. It is the truth: My value has decreased.

There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5

The greater the decrease in the social significance of an art form, the sharper the distinction between criticism and enjoyment by the public.

Lent is a much-needed mentor in an age obsessed with visible, measurable, manageable, and tweetable increase, for it invites us to walk with Jesus and His disciples through darker seasons that we would rather avoid: grief, conflict, misunderstanding, betrayal, restriction, rejection, and pain. Then Easter leads us in celebration of salvation as the stunningly satisfying fruit of Jesus’ sacred decrease.

By itself, partyism is not the most serious threat to democratic self-government. But if it decreases government’s ability to solve serious problems, then it has concrete and potentially catastrophic consequences for people’s lives. I

Tanaka’s lab has pioneered new research on swimming’s effects on two of the biggest hallmarks of aging: high blood pressure and arthritis. “Over the last four or five years, a funky thing happened—we realized that the effects of swimming actually surpassed the magnitude of the effects of walking or cycling,” he tells me. “None of us knew that before.” Average reduction in blood pressure after land-based exercise training is five to seven points. Swimming, he found, reduces blood pressure by an average of nine points—in the blood-pressure world, that’s significant. It also decreases arterial stiffness, a condition in which the walls of your arteries become less elastic and add strain to the heart muscle.

The theory propounded on the Deep Green Resistance Web site and in books by the DGR founders was that the only way to save a modicum of civilization was to systematically destroy the energy infrastructure right now, and maybe right now was too late; 2013 might not have been too late, but the world had dithered itself into four more years of climate collapse. Felicity’s problem with these ideas was that she could see the logic of them—if the world were forced to go local by the destruction of airports, roads, oil and gas pipelines, transmission towers, banks, harbors, the Internet, then, yes, there would be a war, or many wars, but the population would decrease, and the humans who were left would be forced to live the best they could in the environments they found themselves in. Abstractly, Felicity understood the necessity for population collapse of humans in order that other species might have the ghost of a chance, but she thought Ezra

A study has shown that, in Hollywood, female stars tend to find their earnings grow up to the age of thirty-four, then rapidly decrease, whereas their male equivalents reach their maximum earnings at age fifty-one and maintain stable incomes thereafter.

The human collective knows far more today than did the ancient bands. But at the individual level, ancient foragers were the most knowledgeable and skilful people in history. There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5

Finally, don’t underestimate the power of appropriate touch. Hand holding has been found to decrease levels of the stress hormone cortisol. A friendly touch can also be calming. In other words, the simple act of touching another human is a way of connecting with others to protect ourselves—and them.

There is solid data to show that your IQ can change during your teen years, more than anyone had ever expected. Between thirteen and seventeen years of age, one-third of people stay the same, one-third of people decrease their IQ, and a remarkable one-third of people actually significantly raise their IQ.

The irony is that even as digitization is making an increasing amount of information available, it is diminishing the space required for deep, concentrated thought. Today’s near-constant stream of media increases the cost, and thus decreases the frequency, of contemplation. Algorithms promote what seizes attention in response to the human desire for stimulation—and what seizes attention is often the dramatic, the surprising, and the emotional. Whether an individual can find space in this environment for careful thought is one matter. Another is that the now-dominant forms of communication are non-conducive to the promotion of tempered reasoning.

There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened

The human collective knows far more today than did the ancient bands. But at the individual level, ancient foragers were the most knowledgeable and skilful people in history. There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging. Survival in that era required superb mental abilities from everyone.

Having greater self-esteem Looking better in jeans or a bathing suit Being able to participate in sports and other activities I used to enjoy Having a better relationship with my spouse Reversing diabetes, heart disease, or other health risks Decreasing my risk for Alzheimer’s disease and other diseases of aging Having the confidence to apply for the job I really want

concrete example will explain this more clearly. It is known that the atoms of radium, and of other radio-active substances, disintegrate into atoms of lead and helium with the mere passage of time, so that a mass of radium continually diminishes in amount, being replaced by lead and helium. The law which governs the rate of diminution is very remarkable. The amount of radium decreases in precisely the same way as a population would if there were no births, and a uniform death-rate which was the same for every individual, regardless of his age. Or again, it decreases in the same way as the numbers of a battalion of soldiers who are exposed to absolutely random undirected fire. In brief, old age appears to mean nothing to the individual radium atom; it does not die because it has lived its life, but rather because in some way fate knocks at the door.

Only a few of us retain a childlike wonder throughout our lives. A typical life’s journey is one with increasing knowledge but decreasing mental and physical adaptability. Our mindset unknowingly gets trapped in conceptions and categories that we create. As Aristotle observed, as we grow older, we aspire to nothing great and exalted and crave the mere necessities and comforts of existence. Age is a very high price to pay for maturity.

As we are aware, the effect of the vagus nerve is to slow the level of inflammation and keep it in check. If we are sending repeated messages of inflammation over a long time, we are essentially training the vagus nerve to stop having its positive anti-inflammatory effect. This is why it is most common for people to begin experiencing and receiving diagnoses of these autoimmune conditions in their 30s and 40s. After 30+ years of inflammatory signals, the vagus nerve has been trained to stop functioning as an anti-inflammatory intervention. Between the ages of 35 and 40, the vagus tone has decreased significantly and the anti-inflammatory signals stop being sent out. These conditions often arise following the stress of pregnancy, having children, and lacking sleep during the first years of a child’s life—all of which are stressors that decrease vagus nerve function.

But then we learn something else: that the brain doesm't like to be typecast. Just when you think everything is a matter of decrease, of subtraction and division, your brain, your memory, may surprise you. As it it's saying: Don't imagine you can rely on some comforting process of gradual decline--life's much more complicated than that. And so the brain will throw you scraps from time to time, even disengage those familiar memory loops.

Meditation also appears to slow age-related degeneration in our brains. Neurologist Eileen Luders at UCLA looked at the link between age and the volume of the brain’s white matter, which typically shrinks with age. She reported that this decrease was less prominent in meditators as compared to non-meditators. On average, the brains of long-term practitioners appeared to be seven and a half years younger at the age of fifty than the brains of non-meditators.

At the time when the lines begin, in the mid-18th century, life expectancy in Europe and the Americas was around 35, where it had been parked for the 225 previous years for which we have data.3 Life expectancy for the world as a whole was 29. These numbers are in the range of expected life spans for most of human history. The life expectancy of hunter-gatherers is around 32.5, and it probably decreased among the peoples who first took up farming because of their starchy diet and the diseases they caught from their livestock and each other. It returned to the low 30s by the Bronze Age, where it stayed put for thousands of years, with small fluctuations across centuries and regions.4 This period in human history may be called the Malthusian Era, when any advance in agriculture or health was quickly canceled by the resulting bulge in population, though “era” is an odd term for 99.9 percent of our species’ existence.

But for the present age, which prefers the sign to the thing signified, the copy to the original, representation to reality, appearance to essence . . . truth is considered profane, and only illusion is sacred. Sacredness is in fact held to be enhanced in proportion as truth decreases and illusion increases, so that the highest degree of illusion comes to be the highest degree of sacredness.” —Feuerbach, Preface to the second edition 
of The Essence of Christianity

People with low pH levels age quicker for, your skin, your hair, most muscles are made from protein. pH is measured in molecular weight also known as moles per liter. An increase of one point on the pH scale represents a tenfold or one thousand percent decrease in the concentration of hydrogen ions. And a decrease of one point on the pH scale means a thousand percent increase in hydrogen ions. Therefore, a pH of six and eight is not merely two points but twentyfold change.

There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker. Foragers

Later, after many satisfied thirsts, it was neither decrease of desire, nor satiety, that came to me with age; but often, foreseeing the all-too-rapid exhaustion of desire, possession appeared to me of lesser value than the quest, and I came more and more to prefer to quenching thirst, thirst itself; to sensual delight, its promise; to satisfaction, a never-ending expansion of love. How many times then, on the verge of harvesting a joy, have I suddenly turned away, as might have done an ascetic

Ironically, in an age of instant global connection, my certainty about anything has decreased. Rather than receiving truth from an authority, I am reduced to assembling my own certainty from the liquid stream of facts flowing through the web. Truth, with a capital T, becomes truths, plural. I have to sort the truths not just about things I care about, but about anything I touch, including areas about which I can’t possibly have any direct knowledge. That means that in general I have to constantly question what I think I know. We might consider this state perfect for the advancement of science, but it also means that I am more likely to have my mind changed for incorrect reasons. While hooked into the network of networks I feel like I am a network myself, trying to achieve reliability from unreliable parts. And in my quest to assemble truths from half-truths, nontruths, and some noble truths scattered in the flux, I find my mind attracted to fluid ways of thinking (scenarios, provisional belief, subjective hunches) and toward fluid media like mashups, twitterese, and search. But as I flow through this slippery web of

Notwithstanding the wickedness of the antediluvian world, that age was not, as has often been supposed, an era of ignorance and barbarism. The people were granted the opportunity of reaching a high standard of moral and intellectual attainment. They possessed great physical and mental strength, and their advantages for acquiring both religious and scientific knowledge were unrivaled. It is a mistake to suppose that because they lived [83] to a great age their minds matured late; their mental powers were early developed, and those who cherished the fear of God and lived in harmony with his will continued to increase in knowledge and wisdom throughout their life. Could illustrious scholars of our time be placed in contrast with men of the same age who lived before the Flood, they would appear as greatly inferior in mental as in physical strength. As the years of man have decreased, and his physical strength has diminished, so his mental capacities have lessened. There are men who now apply themselves to study during a period of from twenty to fifty years, and the world is filled with admiration of their attainments. But how limited are these acquirements in comparison with those of men whose mental and physical powers were developing for centuries!

The human collective knows far more today than did the ancient bands. But at the individual level, ancient foragers were the most knowledgeable and skilful people in history. There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker.

Prediabetes is easily identified through clinical measurements such as insulin resistance, fasting glucose levels, and glycated hemoglobin (HbA1c, often abbreviated to A1c). Unfortunately, we act on these measurements far less frequently than we should. Early interventions are far easier and far more effective than the more complex and generally ineffective therapies available to treat advanced diabetes. In most cases, all it takes to reverse prediabetes are some straightforward lifestyle choices, including a decrease in dietary sugar and an increase in exercise. These changes require some discipline but are generally simple and even pleasurable.

…the third article we discovered was by Linda Hartling, who ties together research from several areas to propose a model explaining how humiliation can lead to violence. Hartling suggests that humiliation can trigger a series of reactions, including social pain, decreased self-awareness, increased self-defeating behavior, and decreased self-regulation, that ultimately lead to violence. Hartling and colleagues state that “humiliation is not only the most underappreciated force in international relations, it may be the missing link in the search for root causes of political instability and violent conflict…perhaps the most toxic social dynamic of our age.” This connection between humiliation and aggression/violence explains much of what we’re seeing today. Amplified by the reach of social media, dehumanizing and humiliating others are becoming increasingly normalized, along with violence. Now, rather than humiliating someone in front of a small group of people, we have the power to eviscerate someone in front of a global audience of strangers. I know we all have deeply passionate and cultural beliefs, but shame and humiliation will never be effective social justice tools. They are tools of oppression. I remember reading this quote from Elie Wiesel years ago and it’s become a practice for me-even when I’m enraged or afraid: “Never allow anyone to be humiliated in your presence.

higher states of arousal come with decreased abilities to self-quiet. Elevated states of arousal are further coupled with a reduced ability to self-stimulate and self-entertain. This includes reduced abilities to observe, integrate information, and to be creative. In essence, we have less ability to sustain focus on the normal, the baseline, including states of observation, contemplation, and transitions from which ideas spark — what many under the age of twenty now consider a void, proclaiming boredom. We now feel agitated when not externally stimulated; we need to be occupied, entertained. We also have greater troubles quieting, including reaching states of repose, satisfaction, and restorative sleep.

You need to know a lot about your own tiny field of expertise, but for the vast majority of life’s necessities you rely blindly on the help of other experts, whose own knowledge is also limited to a tiny field of expertise. The human collective knows far more today than did the ancient bands. But at the individual level, ancient foragers were the most knowledgeable and skilful people in history. There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up.

Anthony Fauci seems to have not considered that his unprecedented quarantine of the healthy would kill far more people than COVID, obliterate the global economy, plunge millions into poverty and bankruptcy, and grievously wound constitutional democracy globally. We have no way of knowing how many people died from isolation, unemployment, deferred medical care, depression, mental illness, obesity, stress, overdoses, suicide, addiction, alcoholism, and the accidents that so often accompany despair. We cannot dismiss the accusations that his lockdowns proved more deadly than the contagion. A June 24, 2021 BMJ study22 showed that US life expectancy decreased by 1.9 years during the quarantine. Since COVID mortalities were mainly among the elderly, and the average age of death from COVID in the UK was 82.4, which was above the average lifespan,23 the virus could not by itself cause the astonishing decline. As we shall see, Hispanic and Black Americans often shoulder the heaviest burden of Dr. Fauci’s public health adventures. In this respect, his COVID-19 countermeasures proved no exception. Between 2018 and 2020, the average Hispanic American lost around 3.9 years in longevity, while the average lifespan of a Black American dropped by 3.25 years.24 This dramatic culling was unique to America. Between 2018 and 2020, the 1.9 year decrease in average life expectancy at birth in the US was roughly 8.5 times the average decrease in 16 comparable countries, all of which were measured in months, not years.25

Even our brains shrink: at the age of thirty, the brain is a three-pound organ that barely fits inside the skull; by our seventies, gray-matter loss leaves almost an inch of spare room. That’s why elderly people like my grandfather are so much more prone to cerebral bleeding after a blow to the head—the brain actually rattles around inside. The earliest portions to shrink are generally the frontal lobes, which govern judgment and planning, and the hippocampus, where memory is organized. As a consequence, memory and the ability to gather and weigh multiple ideas—to multitask—peaks in midlife and then gradually declines. Processing speeds start decreasing well before age forty (which may be why mathematicians and physicists commonly do their best work in their youth).

In human studies, black cohosh has been found to decrease hot flashes associated with menopause. Unlike conventional estrogen effects on individuals predisposed to breast cancer, black cohosh has been shown in laboratory studies to inhibit cancer cells. Most studies used doses of 20–80 mg twice daily, providing 4–8 mg triterpene glycosides for up to six months. Melatonin—This hormone is produced in the pineal gland that, among other functions, helps sleep. Melatonin levels decline with age and may lead to the sleep disturbances common during menopause. Melatonin has been shown in laboratory studies to inhibit the growth of breast cancer cells. Melatonin acts as an anti-inflammatory and antioxidant in the brain and other tissues like the intestine. Studies show that low melatonin levels increase breast cancer risk in women. So if you are having trouble sleeping consider 3–6 mg of melatonin before bed. It may boost your immune system and help you sleep.

Community spaces can make a difference, too. The prevalence of “third places” where people congregate has been shown to make an impact, including increasing trust, decreasing loneliness, and creating a greater sense of attachment to where we live.41 After the first and second places of home and work, the third place is an alternate location to spend leisure time.42 Examples of third places are parks, libraries, coffee shops, places of worship, community pools, or local watering holes. Density of third places — notably, eateries — has been shown to improve cognitive functioning.43 Having a third place significantly influences perceived social connectedness, even if one doesn’t use them regularly. Third places can be particularly useful in bringing together people of all ages. More than 90% believe that intergenerational activities, such as those at third places, help reduce loneliness across all ages, drastically cutting down the prevalence and harmful effects of loneliness.44

...I shall let [Anne] Wallace put the case herself, at what I think is necessary length: 'As travel in general becomes physically easier, faster, and less expensive, more people want and are able to arrive at more destinations with less unpleasant awareness of their travel process. At the same time the availability of an increasing range of options in conveyance, speed, price, and so forth actually encouraged comparisons of these different modes...and so an increasingly positive awareness of process that even permitted semi-nostalgic glances back at the bad old days...Then, too, although local insularity was more and more threatened...people also quite literally became more accustomed to travel and travellers, less fearful of 'foreign' ways, so that they gradually became able to regard travel as an acceptable recreation. Finally, as speeds increased and costs decreased, it simply ceased to be true that the mass of people were confined to that circle of a day's walk: they could afford both the time and the money to travel by various means and for purely recreational purposes...And as walking became a matter of choice, it became a possible positive choice: since the common person need not necessarily be poor. Thus, as awareness of process became regarded as advantageous, 'economic necessity' became only one possible reading (although still sometimes a correct one) in a field of peripatetic meanings that included 'aesthetic choice'.' It sounds a persuasive case. It is certainly possible that something like the shift in consciousness that Wallace describes may have taken place by the 'end' (as conventionally conceived) of the Romantic period, and influenced the spread of pedestrianism in the 1820s and 1830s; even more likely that such a shift was instrumental in shaping the attitudes of Victorian writing in the railway age, and helped generate the apostolic fervour with which writers like Leslie Stephen and Robert Louis Stevenson treated the walking tour. But it fails to account for the rise of pedestrianism as I have narrated it.

To make matters worse, as you get older, your cells gradually become less sensitive to insulin's effects, so insulin levels must rise even more to produce the same results. This leads to a state of insulin resistance, which leads to even more insulin production. Over time, these increasing insulin levels, especially when combined with a poor diet, promote the weight gain and increase in body fat so typical of the aging process. It's not a pretty picture, but this deterioration is far from inevitable. Commonsense lifestyle changes can help you keep your insulin levels under control: Following the major themes of our TRANSCEND program will help you keep your insulin at low, youthful levels. Maintaining a regular vigorous exercise routine burns blood sugar and drives it into your muscle cells, decreasing your body's need for insulin. Following our recommendations for a low-sugar, low-glycemic-load diet will lower insulin levels further. Finally, controlling your stress will lower your cortisol level and avoid the vicious cycle of cortisol-raising insulin.

It is evident that wealth is even more unevenly distributed than income and that the gap is widening. Since 1976, wealth has increased by 63 percent for the wealthiest 1 percent of the population and by 71 percent for the top 20 percent. Wealth has decreased by 43 percent for the bottom 40 percent of the U.S. population (Economic Policy Institute 2011). The widening gap has multiple causes. First, shifts in the U.S. tax code have lowered the top tax rate from 91 percent in the years from 1950 to 1963, to 35 percent from 2003 to 2012, allowing the wealthy to retain far more of their income (Tax Policy Center 2012). Second, wages for most U.S. families have stagnated since the early 1970s. Moreover, credit card, education, and mortgage debt have skyrocketed. Finally, the collapse of the housing market beginning in 2007 dramatically affected many middleclass families who held a significant portion of their wealth in the value of their home. By 2012, fully 31 percent of all homeowners owed more on their mortgages than their homes were worth (Zillow 2012).

Women select short-term sexual relationships when men cannot improve their children’s survival, when there are too few men, or when their upbringing has signaled that men are unreliable investors in their progeny. Short-term relationships for women often amount to serial monogamy in response to a population of males, none of whom can or will provide sustained economic and emotional commitment. And if she can maintain her attractiveness in the face of her increasing age, decreasing looks, and the handicap (from a prospective partner’s viewpoint) of already born children, she can also gain the advantage of genetic diversity and perhaps better genetic quality in her children. But the most secure and stable route is to attract a male who will commit, providing the long-term assistance and resources that she needs to raise multiple offspring simultaneously. Unfortunately that idea has occurred to other women also and she is in a competitive market-place. The currency of the marketplace is what men want in a female partner. To trade successfully, she must advertise her assets by showing that she has more desirable qualities than her female rivals.

In other words, the average forager had wider, deeper and more varied knowledge of her immediate surroundings than most of her modern descendants. Today, most people in industrial societies don’t need to know much about the natural world in order to survive. What do you really need to know in order to get by as a computer engineer, an insurance agent, a history teacher or a factory worker? You need to know a lot about your own tiny field of expertise, but for the vast majority of life’s necessities you rely blindly on the help of other experts, whose own knowledge is also limited to a tiny field of expertise. The human collective knows far more today than did the ancient bands. But at the individual level, ancient foragers were the most knowledgeable and skilful people in history. There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker.

What is the difference then between reason and instinct?” “The difference is very great, William, as I will explain to you; but I must first observe, that it has been the custom to say that man is governed by reason, and animals by instinct, alone. This is an error. Man has instinct as well as reason; and animals, although chiefly governed by instinct, have reasoning powers.” “In what points does man show that he is led by instinct?” “When a child is first born, William, it acts by instinct only: the reasoning powers are not yet developed; as we grow up, our reason becomes every day more matured, and gains the mastery over our instinct, which decreases in proportion.” “Then when we have grown to a good old age, I suppose we have no instinct left in us?” “Not so, my dear boy; there is one and a most powerful instinct implanted in man which never deserts him on this side of the grave. It is the fear, not of death, but of utter annihilation, that of becoming nothing after death. This instinctive feeling could not have been so deeply implanted in us, but as an assurance that we shall not be annihilated after death, but that our souls shall still exist, although our bodies shall have perished. It may be termed the instinctive evidence of a future existence.

In North America, there is no nostalgia for the postwar period, quite simply because the Trente Glorieuses never existed there: per capita output grew at roughly the same rate of 1.5–2 percent per year throughout the period 1820–2012. To be sure, growth slowed a bit between 1930 and 1950 to just over 1.5 percent, then increased again to just over 2 percent between 1950 and 1970, and then slowed to less than 1.5 percent between 1990 and 2012. In Western Europe, which suffered much more from the two world wars, the variations are considerably greater: per capita output stagnated between 1913 and 1950 (with a growth rate of just over 0.5 percent) and then leapt ahead to more than 4 percent from 1950 to 1970, before falling sharply to just slightly above US levels (a little more than 2 percent) in the period 1970–1990 and to barely 1.5 percent between 1990 and 2012. Western Europe experienced a golden age of growth between 1950 and 1970, only to see its growth rate diminish to one-half or even one-third of its peak level during the decades that followed. [...] If we looked only at continental Europe, we would find an average per capita output growth rate of 5 percent between 1950 and 1970—a level well beyond that achieved in other advanced countries over the past two centuries. These very different collective experiences of growth in the twentieth century largely explain why public opinion in different countries varies so widely in regard to commercial and financial globalization and indeed to capitalism in general. In continental Europe and especially France, people quite naturally continue to look on the first three postwar decades—a period of strong state intervention in the economy—as a period blessed with rapid growth, and many regard the liberalization of the economy that began around 1980 as the cause of a slowdown. In Great Britain and the United States, postwar history is interpreted quite differently. Between 1950 and 1980, the gap between the English-speaking countries and the countries that had lost the war closed rapidly. By the late 1970s, US magazine covers often denounced the decline of the United States and the success of German and Japanese industry. In Britain, GDP per capita fell below the level of Germany, France, Japan, and even Italy. It may even be the case that this sense of being rivaled (or even overtaken in the case of Britain) played an important part in the “conservative revolution.” Margaret Thatcher in Britain and Ronald Reagan in the United States promised to “roll back the welfare state” that had allegedly sapped the animal spirits of Anglo-Saxon entrepreneurs and thus to return to pure nineteenth-century capitalism, which would allow the United States and Britain to regain the upper hand. Even today, many people in both countries believe that the conservative revolution was remarkably successful, because their growth rates once again matched continental European and Japanese levels. In fact, neither the economic liberalization that began around 1980 nor the state interventionism that began in 1945 deserves such praise or blame. France, Germany, and Japan would very likely have caught up with Britain and the United States following their collapse of 1914–1945 regardless of what policies they had adopted (I say this with only slight exaggeration). The most one can say is that state intervention did no harm. Similarly, once these countries had attained the global technological frontier, it is hardly surprising that they ceased to grow more rapidly than Britain and the United States or that growth rates in all of these wealthy countries more or less equalized [...] Broadly speaking, the US and British policies of economic liberalization appear to have had little effect on this simple reality, since they neither increased growth nor decreased it.

HUNGER AND OBESITY The change in diets around the world is also creating a global obesity epidemic—and in its wake a global diabetes epidemic—even as more than 900 million people in the world still suffer from chronic hunger. In the United States, where many global trends begin, the weight of the average American has increased by approximately twenty pounds in the last forty years. A recent study projects that half the adult population of the United States will be obese by 2030, with one quarter of them “severely obese.” At a time when hunger and malnutrition are continuing at still grossly unacceptable levels in poor countries around the world (and in some pockets within developed countries), few have missed the irony that simultaneously obesity is at record levels in developed countries and growing in many developing countries. How could this be? Well, first of all, it is encouraging to note that the world community has been slowly but steadily decreasing the number of people suffering from chronic hunger. Secondly, on a global basis, obesity has more than doubled in the last thirty years. According to the World Health Organization, almost 1.5 billion adults above the age of twenty are overweight, and more than a third of them are classified as obese. Two thirds of the world’s population now live in countries where more people die from conditions related to being obese and overweight than from conditions related to being underweight. Obesity represents a major risk factor for the world’s leading cause of death—cardiovascular diseases, principally heart disease and stroke—and is the major risk factor for diabetes, which has now become the first global pandemic involving a noncommunicable disease.* Adults with diabetes are two to four times more likely to suffer heart disease or a stroke, and approximately two thirds of those suffering from diabetes die from either stroke or heart disease.† The tragic increase in obesity among children is particularly troubling; almost 17 percent of U.S. children are obese today, as are almost 7 percent of all children in the world. One respected study indicates that 77 percent of obese children will suffer from obesity as adults. If there is any good news in the latest statistics, it is that the prevalence of obesity in the U.S. appears to be reaching a plateau, though the increases in childhood obesity ensure that the epidemic will continue to grow in the future, both in the U.S. and globally. The causes of this surge in obesity are both simple—in that people are eating too much and exercising

The Vishnu Purana states that, the Kali Yuga will be characterized by: “Kings of churlish spirit, violent temper, and ever addicted to falsehood and wickedness. They will inflict death on women, children, and cows; they will seize upon the property of their subjects; they will be of limited power, and will for the most part rapidly rise and fall; their lives will be short, their desires insatiable, and they will display but little piety. Wealth and piety will decrease day by day, until the world will be wholly depraved. Then property alone will confer rank; wealth will be the only source of devotion; passion will be the sole bond of union between the sexes; falsehood will be the only means of success in litigation; and women will be objects merely of sensual gratification. Earth will be venerated but for its mineral treasures. Dishonesty will be the universal means of subsistence; menace and presumption will be substituted for learning. The people, unable to bear the heavy burdens imposed upon them by their avaricious sovereigns, will take refuge amongst the valleys of the mountains, and will be glad to feed upon wild honey, herbs, roots, fruits, flowers, and leaves. Thus in the Kali age shall decay constantly proceed, until the human race approaches its annihilation.

The human collective knows far more today than did the ancient bands. But at the individual level, ancient foragers were the most knowledgeable and skilful people in history. There is some evidence that the size of the average Sapiens brain has actually decreased since the age of foraging.5 Survival in that era required superb mental abilities from everyone. When agriculture and industry came along people could increasingly rely on the skills of others for survival, and new ‘niches for imbeciles’ were opened up. You could survive and pass your unremarkable genes to the next generation by working as a water carrier or an assembly-line worker. Foragers mastered not only the surrounding world of animals, plants and objects, but also the internal world of their own bodies and senses. They listened to the slightest movement in the grass to learn whether a snake might be lurking there. They carefully observed the foliage of trees in order to discover fruits, beehives and bird nests. They moved with a minimum of effort and noise, and knew how to sit, walk and run in the most agile and efficient manner. Varied and constant use of their bodies made them as fit as marathon runners. They had physical dexterity that people today are unable to achieve even after years of practising yoga or t’ai chi.

biomedical view, for its part, increasingly recognizes the power of things like meditation and traditional talk therapy to render concrete structural changes in brain physiology that are every bit as “real” as the changes wrought by pills or electroshock therapy. A study published by researchers at Massachusetts General Hospital in 2011 found that subjects who practiced meditation for an average of just twenty-seven minutes a day over a period of eight weeks produced visible changes in brain structure. Meditation led to decreased density of the amygdala, a physical change that was correlated with subjects’ self-reported stress levels—as their amygdalae got less dense, the subjects felt less stressed. Other studies have found that Buddhist monks who are especially good at meditating show much greater activity in their frontal cortices, and much less in their amygdalae, than normal people.n Meditation and deep-breathing exercises work for similar reasons as psychiatric medications do, exerting their effects not just on some abstract concept of mind but concretely on our bodies, on the somatic correlates of our feelings. Recent research has shown that even old-fashioned talk therapy can have tangible, physical effects on the shape of our brains. Perhaps Kierkegaard was wrong to say that the man who has learned to be in anxiety has learned the most important, or the most existentially meaningful, thing—perhaps the man has only learned the right techniques for controlling his hyperactive amygdala.o

If you want to make money at some point, remember this, because this is one of the reasons startups win. Big companies want to decrease the standard deviation of design outcomes because they want to avoid disasters. But when you damp oscillations, you lose the high points as well as the low. This is not a problem for big companies, because they don't win by making great products. Big companies win by sucking less than other big companies.” - “The place to fight design wars is in new markets, where no one has yet managed to establish any fortifications. That's where you can win big by taking the bold approach to design, and having the same people both design and implement the product. Microsoft themselves did this at the start. So did Apple. And Hewlett- Packard. I suspect almost every successful startup has.” - “Great software, likewise, requires a fanatical devotion to beauty. If you look inside good software, you find that parts no one is ever supposed to see are beautiful too.” - “The right way to collaborate, I think, is to divide projects into sharply defined modules, each with a definite owner, and with interfaces between them that are as carefully designed and, if possible, as articulated as programming languages. Like painting, most software is intended for a human audience. And so hackers, like painters, must have empathy to do really great work. You have to be able to see things from the user's point of view.” - “It turns out that looking at things from other people's point of view is practically the secret of success.” - “Part of what software has to do is explain itself. So to write good software you have to understand how little users understand. They're going to walk up to the software with no preparation, and it had better do what they guess it will, because they're not going to read the manual.

Did you know that if you’re a middle-aged woman, you have only a small window of opportunity between the beginning of perimenopause and the start of menopause to start estrogen replacement therapy to protect not only your brain but also your bones and cardiovascular system? I did not, until I dug into the science, because as a woman who was diagnosed with a stage 0 breast lump, I was scared off like so many of us from the results of the Women’s Health Initiative, which got blasted out all over the news and initially showed a link between estrogen replacement therapy and breast cancer, but guess what? That study had so many flaws, its findings are little more than useless and possibly harmful. Worse, women like me without uteri show a decrease in breast cancer with estrogen replacement therapy. But this information never made it either into the headlines or into our gynecologists’ offices. I had to find it in scientific publications such as The Lancet online. In fact, get this: Our medical system barely trains gynecologists in menopausal medicine. A recent study found that only 20 percent of ob-gyn residency programs in the U.S. provide any menopause training. Yes, any. Which means that 80 percent of all gynecological residents in school today are getting no training whatsoever in post-reproductive women’s health. These are people whose job it is to know everything going on in our ladyparts, but they have not been taught the basic tenets of how to care for either us or our plumbing after we stop menstruating. And by “us” I mean 30 percent of all women alive on earth at any given moment. Half of my middle-aged female friends deal with chronic urinary tract infections. Oh, well, we think, throwing up our hands in defeat and consuming far too many antibiotics than are rational or safe or even good for the future safety of humanity. It took Dr. Rachel Rubin, a urologist in Washington, D.C., reaching out to me over Twitter to explain that UTIs in menopausal women do not have to be recurrent. They can be mitigated with, yes, vaginal estrogen. Not once was I ever

This, in turn, has given us a “unified theory of aging” that brings the various strands of research into a single, coherent tapestry. Scientists now know what aging is. It is the accumulation of errors at the genetic and cellular level. These errors can build up in various ways. For example, metabolism creates free radicals and oxidation, which damage the delicate molecular machinery of our cells, causing them to age; errors can build up in the form of “junk” molecular debris accumulating inside and outside the cells. The buildup of these genetic errors is a by-product of the second law of thermodynamics: total entropy (that is, chaos) always increases. This is why rusting, rotting, decaying, etc., are universal features of life. The second law is inescapable. Everything, from the flowers in the field to our bodies and even the universe itself, is doomed to wither and die. But there is a small but important loophole in the second law that states total entropy always increases. This means that you can actually reduce entropy in one place and reverse aging, as long as you increase entropy somewhere else. So it’s possible to get younger, at the expense of wreaking havoc elsewhere. (This was alluded to in Oscar Wilde’s famous novel The Picture of Dorian Gray. Mr. Gray was mysteriously eternally young. But his secret was the painting of himself that aged horribly. So the total amount of aging still increased.) The principle of entropy can also be seen by looking behind a refrigerator. Inside the refrigerator, entropy decreases as the temperature drops. But to lower the entropy, you have to have a motor, which increases the heat generated behind the refrigerator, increasing the entropy outside the machine. That is why refrigerators are always hot in the back. As Nobel laureate Richard Feynman once said, “There is nothing in biology yet found that indicates the inevitability of death. This suggests to me that it is not at all inevitable and that it is only a matter of time before biologists discover what it is that is causing us the trouble and that this terrible universal disease or temporariness of the human’s body will be cured.

There is no fault that can’t be corrected [in natural wine] with one powder or another; no feature that can’t be engineered from a bottle, box, or bag. Wine too tannic? Fine it with Ovo-Pure (powdered egg whites), isinglass (granulate from fish bladders), gelatin (often derived from cow bones and pigskins), or if it’s a white, strip out pesky proteins that cause haziness with Puri-Bent (bentonite clay, the ingredient in kitty litter). Not tannic enough? Replace $1,000 barrels with a bag of oak chips (small wood nuggets toasted for flavor), “tank planks” (long oak staves), oak dust (what it sounds like), or a few drops of liquid oak tannin (pick between “mocha” and “vanilla”). Or simulate the texture of barrel-aged wines with powdered tannin, then double what you charge. (““Typically, the $8 to $12 bottle can be brought up to $15 to $20 per bottle because it gives you more of a barrel quality. . . . You’re dressing it up,” a sales rep explained.) Wine too thin? Build fullness in the mouth with gum arabic (an ingredient also found in frosting and watercolor paint). Too frothy? Add a few drops of antifoaming agent (food-grade silicone oil). Cut acidity with potassium carbonate (a white salt) or calcium carbonate (chalk). Crank it up again with a bag of tartaric acid (aka cream of tartar). Increase alcohol by mixing the pressed grape must with sugary grape concentrate, or just add sugar. Decrease alcohol with ConeTech’s spinning cone, or Vinovation’s reverse-osmosis machine, or water. Fake an aged Bordeaux with Lesaffre’s yeast and yeast derivative. Boost “fresh butter” and “honey” aromas by ordering the CY3079 designer yeast from a catalog, or go for “cherry-cola” with the Rhône 2226. Or just ask the “Yeast Whisperer,” a man with thick sideburns at the Lallemand stand, for the best yeast to meet your “stylistic goals.” (For a Sauvignon Blanc with citrus aromas, use the Uvaferm SVG. For pear and melon, do Lalvin Ba11. For passion fruit, add Vitilevure Elixir.) Kill off microbes with Velcorin (just be careful, because it’s toxic). And preserve the whole thing with sulfur dioxide. When it’s all over, if you still don’t like the wine, just add a few drops of Mega Purple—thick grape-juice concentrate that’s been called a “magical potion.” It can plump up a wine, make it sweeter on the finish, add richer color, cover up greenness, mask the horsey stink of Brett, and make fruit flavors pop. No one will admit to using it, but it ends up in an estimated 25 million bottles of red each year. “Virtually everyone is using it,” the president of a Monterey County winery confided to Wines and Vines magazine. “In just about every wine up to $20 a bottle anyway, but maybe not as much over that.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,

help with cardiovascular issues, try the Zona Plus, a digitally controlled handheld device that uses the science behind isometric exercise to increase both vascular flexibility (thus decreasing blood pressure) and the production and flow of nitric oxide throughout the body, which is linked to treating various cardiovascular conditions, erectile dysfunction, and muscle fatigue.

in my view, no other variable has changed in the last twenty years that could possibly account for a tremendous rise in youthful ED and low libido. For example, unhealthy lifestyles, such as poor diet leading to obesity, substance abuse and smoking (factors historically correlated with organic ED) have not changed proportionately, or have decreased, in the last 20 years. Obesity rates in U.S. men aged 20–40 increased only 4% between 1999 and 2008[45]; rates of illicit drug use among US citizens aged 12 or older have been relatively stable over the last 15 years;[46] and smoking rates for US adults declined from 25% in 1993 to 19% in 2011.[47

During disintegrative trend reversals, these processes work in reverse. Abatement of elite overproduction decreases intraelite competition. Additionally, there is another curious dynamic that tends to increase intraelite homogeneity, the “closing of the patriciate”, in which the established elites close their ranks to newcomers and dramatically reduce, or even reverse upward social mobility.

The entire company, he said, would restructure itself around what he called “two-pizza teams.” Employees would be organized into autonomous groups of fewer than ten people—small enough that, when working late, the team members could be fed with two pizza pies. These teams would be independently set loose on Amazon’s biggest problems. They would likely compete with one another for resources and sometimes duplicate their efforts, replicating the Darwinian realities of surviving in nature. Freed from the constraints of intracompany communication, Bezos hoped, these loosely coupled teams could move faster and get features to customers quicker. There were some head-scratching aspects to Bezos’s two-pizza-team concept. Each group was required to propose its own “fitness function”—a linear equation that it could use to measure its own impact without ambiguity. For example, a two-pizza team in charge of sending advertising e-mails to customers might choose for its fitness function the rate at which these messages were opened multiplied by the average order size those e-mails generated. A group writing software code for the fulfillment centers might home in on decreasing the cost of shipping each type of product and reducing the time that elapsed between a customer’s making a purchase and the item leaving the FC in a truck. Bezos wanted to personally approve each equation and track the results over time. It would be his way of guiding a team’s evolution.

People tried to space their children three to four years apart. Women did so by nursing their children around the clock and until a late age (around-the-clock suckling significantly decreases the chances of getting pregnant).

Compounds like N-acetyl cysteine, vitamin C and glutathione provide antioxidant effects and may decrease age-related genomic instability. Natural polyphenols in green tea, turmeric and berries also have antioxidant and anti-mutagenic properties. Maintaining adequate levels of antioxidants through diet or supplements may support genomic stability.

You may be wondering how chronic overstimulation can induce two seemingly opposite effects. First, it can increase dopamine activity (sensitisation via DeltaFosB). Second, it can decrease dopamine activity (desensitisation via CREB124). The answer is that it’s mostly about timing. But it’s also about the neurological differences between wanting and liking.[135] Sensitisation leads to high spikes of dopamine in response to cues and triggers associated with use. The dopamine spikes occur before ingesting the drug or masturbating to porn, and are experienced as cravings to use. However, on exposure to the same old stimuli less dopamine (and less opioids) are released (desensitisation). This dampening of pleasure occurs during drug use or while masturbating to porn. The activity is experienced as less pleasurable, increasing cravings for more. Thus, two mechanisms once beneficial to our animal ancestors have unwanted consequences in the age of porn tube sites and omnipresent junk food. Sensitisation leads to greater wanting or more intense cravings, while desensitisation leads to less liking or a decline in overall pleasure.[136] This disparity acts as a double-edged sword that drives compulsive use: overpowering cravings to use (sensitisation) combined with less fulfilment from both everyday activities and from the problematic behaviours (desensitisation). Brain scan studies confirm that porn addicts have greater reward system activation in the craving phase (wanting), but do not like porn any more than non-addicts.

First, because in a multi-age group, children learn that there are those who are more advanced and those who are less advanced than them in every skill. This is how tolerance is learned and thus the constant need to compete and demonstrate abilities is decreased.

Soymilk also appears to have the additional benefits of reducing risk of breast3227 and prostate3228 cancers, improving gut health,3229 and decreasing inflammation3230 and free radical DNA damage compared to rice milk or dairy milk.3231 It can also improve insulin resistance3232 and help with stroke rehabilitation, improving walking speed, exercise endurance, grip strength, and muscle functionality,3233 as well as lower blood pressure better than dairy milk.3234 Soymilk can even lower your LDL cholesterol as much as 25 percent after just twenty-one days.3235 Nutritionally, soymilk is considered the best choice for replacing dairy milk in the human diet.

For excess hair: Women may be successfully treated with metformin, spironolactone, birth control pills, and/or oral estrogen. Spironolactone somehow produces more healthy hair growth for them. It can both improve scalp hair thickness and decrease excess hair. It is a mild diuretic, anti-inflammatory, and testosterone blocker.

For example, older men and women with an average age of seventy on a generic twenty-four-week strength training program with three sessions a week experienced about a 10 percent increase in leg muscle mass, a 40 percent increase in lower and upper body strength, and about a 20 percent decrease in sit-to-stand time,5575 which is a measure of physical function that can predict fall risk.5576

Amla has also been shown to reduce triglycerides,6918 improve blood fluidity, reduce markers of oxidative DNA damage6919 and systemic inflammation,6920 improve blood sugar control in diabetics,6921 and may decrease the effects of stress on the heart.

When you know, understand and apply the 7 foundations you will have the solution to the problems that plague many people in their 40s and beyond… Lost muscle and strength Decreased mobility and flexibility Lost confidence in their ability to train intensely Your body does change when you age, and in this book, you will discover exactly how it does so. More importantly, though, you will find out precisely how you need to adjust your training to compensate for those changes.

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One of the most important teachings in the Dharma is that while scholarship is valued, having an open heart is valued even more. If nothing around us has any genuine substance, then all the happiness or unhappiness we feel comes from our own mind. It's not what happens to you that matters, but the way you interpret things. The greatest obstacle to our own happiness is too much thinking. Thinking about the past, especially going over bad things that have happened in our minds again and again, serves no purpose. It is completely useless mental activity. In fact, it is worse than useless, because it can only harm our happiness. Meditation combats stress by lowering blood pressure and the heart rate. it improves the immune function so you don't get colds and flu so much. It boosts DHEA production - that's the only hormone that decreases directly with age - slowing down aging.

God created us as social, relational persons. Yet the current way of life in developed countries is greatly reducing the quantity and quality of our relationships. When you add the high degree of mobility, the strong sense of individualism, and the decreased opportunities for informal public life, isolation and loneliness become increasingly common. According to one recent study, 40% of adults between the ages of 45 and 49 said they were lonely, a rate of loneliness that has doubled since the 1980s. Based on a 2004 study, one in four Americans said they had no one whom they could talk to about personal troubles. If family members were not counted, that number doubled. More than half of those surveyed had no one outside their immediate family with whom they could share important issues. In short, we have fewer people to lean on. In nearly every American setting, people are living relationally impoverished lives marked by a sense of isolation. Far too many people are lonely and alone. This issue of isolation is compounded by a sense of detachment from place. In a highly mobile society, people rarely feel rooted geographically. We live as nomads, both figuratively and literally.

If we truly want to end violence in our communities, we must come to understand, as discussed in the final chapter, the ways in which mass incarceration increases—not decreases—violence and multiplies its harms. But at the same time, we ought not be misled by those who insist that violent crime has driven the rise of this unprecedented system of racial and social control. The uncomfortable reality is that a literal war has been waged on our most vulnerable communities, and convictions for relatively minor, nonviolent offenses have propelled mass incarceration. In many states, including Colorado and Maryland, people convicted of drug offenses now constitute the single largest category of people admitted to prison.30 People of color are convicted of drug offenses at rates out of all proportion to their drug crimes, a fact that has greatly contributed to the emergence of a vast new racial undercaste—a system of mass incarceration that governs the lives of millions of people inside and outside of prison walls.

In 2016, The Journal of the American Medical Association released an observational study that looked at more than 2,000 women between the ages of 27 and 70 who had undergone conventional breast cancer treatment. After analyzing this large group of women for four years, researchers determined that when women fasted 13 hours or more, they had a 64 percent less chance of recurrence of breast cancer. This is largely because fasting created a significant decrease in hemoglobin A1c, an indicator of blood glucose levels, and C-reactive protein,

In 2016, The Journal of the American Medical Association released an observational study that looked at more than 2,000 women between the ages of 27 and 70 who had undergone conventional breast cancer treatment. After analyzing this large group of women for four years, researchers determined that when women fasted 13 hours or more, they had a 64 percent less chance of recurrence of breast cancer. This is largely because fasting created a significant decrease in hemoglobin A1c, an indicator of blood glucose levels, and C-reactive protein, an indicator of inflammation.

2016, The Journal of the American Medical Association released an observational study that looked at more than 2,000 women between the ages of 27 and 70 who had undergone conventional breast cancer treatment. After analyzing this large group of women for four years, researchers determined that when women fasted 13 hours or more, they had a 64 percent less chance of recurrence of breast cancer. This is largely because fasting created a significant decrease in hemoglobin A1c, an indicator of blood glucose levels, and C-reactive protein, an indicator of inflammation.

The idea of a world that encourages moral hypocrisy through punitive shaming is often associated, thanks in no small part to The Scarlet Letter, with religion. But the contemporary West demonstrates a fascinating paradox. As the importance of religion has decreased and expressive individualism has increased, the result has not been a culture-wide renewal of compassion, tolerance, and understanding. Instead, the social internet has documented an astonishingly ascendant shame culture that digitally punishes and erases those who run afoul of its values.

If people just concentrate on decreasing their intake of animal foods, they may end up increasing their consumption of highly processed junk, like Coke and Wonder Bread.

As a bonus, the same cardamom dose over two to three months can significantly improve markers of inflammation and oxidative stress,1911 and be a safe, cheap, convenient way to decrease the level of triglycerides in the blood by about twenty points (mg/dL).

Depending on the season, vaccination typically reduces the risk of getting the flu by about 40 to 50 percent.4669 So, in healthy younger adults, we can say with moderate certainty that we can decrease the risk of getting the flu from about 2 percent each year down to just under 1 percent.4670

Using diversions like television, computer games, alcohol, and drugs, we try to ignore the realities of aging, illness, death, and the impermanence of the things we cherish. If we allow ourselves to be overwhelmed by our fears, we will suffer, and the seed of fear in us will grow stronger. But when we are mindful, we use the energy of mindfulness to embrace our fear. Every time fear is embraced by mindfulness, the energy of fear decreases before going back down to the depths of our consciousness as a seed.

Prohibition led to a sharp decrease in the number of Americans consuming and becoming addicted to alcohol. Rates of public drunkenness and alcohol-related liver disease decreased by half during this period in the absence of new remedies to treat addiction.